Kufotokozera
TheAmyloid β-Protein (1-6) fragment yaperekedwa ngati njira yabwino yolumikizirana ya 2+ kuti iwunikire zopereka za zotsalira za histidine (Zake, Zake mu mbewa ndi Zake, Zake, Zake mu chidutswa cha anthu) ku Ab-Cu.Zolinga za okosijeni za Amyloidβ-Mapuloteni (1-6) ndi zotsalira za histidine zomwe zimagwirizanitsa ndi ayoni achitsulo.Copper amalumikizana ndi Aβ mu senile plaques of Alzheimer's disease, ndi Amyloidβ-Mapuloteni (1-6) akuphatikizidwa pakugwirizanitsa 2+ ion yamkuwa.Copper 2+ ndi zinc 2+ zakhala zikuphatikizidwa mu neurotoxicity ndi kuwonongeka kwakukulu kwaulere kwa amyloid [1].Beta-amyloid (1-16) ndiye njira yaying'ono kwambiri ya amino acid ndipo imawonetsa mawonekedwe a Cu coordination ophatikiza ma histidines atatu (His6, His13, ndi His14).Beta-Amyloidβ-Mapuloteni (1-6) ayenera kuphatikizidwa muzitsulo zachitsulo [2].Beta-amyloid yaumunthu imalumikizana ndi ayoni a zinki kudzera mu domain yake yomanga zitsulo 1-16.C-mchira wa maunyolo awiri a polypeptide a makoswe Aβ(1-16) dimer ndizoyang'anana wina ndi mzake, zomwe zimalepheretsa kusonkhana kwa makoswe Aβ dimers kukhala oligomers.
Zofotokozera
Maonekedwe: ufa woyera mpaka woyera
Kuyera (HPLC):≥98.0%
Kusayera Kumodzi:≤2.0%
Acetate Content(HPLC): 5.0%~12.0%
M'madzi (Karl Fischer):≤10.0%
Zinthu za Peptide:≥80.0%
Kupaka ndi Kutumiza: Kutentha kochepa, kulongedza kwa vacuum, kulondola kwa mg ngati pakufunika.
Mungayitanitsa Bwanji?
1. Contact us directly by phone or email: +86-13735575465, sales1@gotopbio.com.
2. Kuitanitsa pa intaneti.Chonde lembani fomu yoyitanitsa pa intaneti.
3. Perekani dzina la peptide, CAS No. kapena kutsatizana, chiyero ndi kusinthidwa ngati kuli kofunikira, kuchuluka kwake, ndi zina zotero.
4. Order conformation ndi mgwirizano wamalonda wosainidwa bwino ndi NDA (mgwirizano wosawululira) kapena mgwirizano wachinsinsi.
5. Tidzasintha mosalekeza momwe madongosolo akuyendera munthawi yake.
6. Peptide yoperekedwa ndi DHL, Fedex kapena ena, ndi HPLC, MS, COA idzaperekedwa pamodzi ndi katundu.
7. Ndondomeko yobwezera ndalama idzatsatiridwa ngati pali kusiyana kulikonse kwa khalidwe lathu kapena ntchito yathu.
8. Pambuyo pogulitsa ntchito: Ngati makasitomala athu ali ndi mafunso okhudza peptide yathu panthawi yoyesera, chonde muzimasuka kutilankhulana nafe ndipo tidzayankha posachedwa.
Zogulitsa zonse zamakampani zimangogwiritsidwa ntchito pazofufuza zasayansi, izo'ndizoletsedwa kugwiritsidwa ntchito mwachindunji ndi munthu aliyense pathupi la munthu.
FAQ:
Ndi malingaliro otani ndikayamba kugwiritsa ntchito ma peptides?
Mukakonzeka kugwiritsidwa ntchito, tsatirani njira zomwe zili pansipa kuti musungunule ma peptides kuti akhalebe abwino.
1, musanatsegule botolo ndikuyesa gawo la peptide, litenthetseni kuti lifike kutentha, ndipo nthawi yotentha imayenera kukhala ola limodzi.
2. Yezerani mwachangu kuchuluka kofunikira m'malo oyera akunja.
3. Sungani ma peptides otsala mufiriji pansi -20℃, onjezerani ma desiccants ndikuwasunga mu chidebe chopanda mpweya.
Ndimakhala kunja, ndipo zidzatenga masiku angapo kuti ndiperekedwe ndi chilolezo cha kasitomu.Kodi izi zikhudza kafukufuku wanga?
Mumalandira peptides mu lyophilized ufa phukusi, ndi peptides nthawi zambiri kusungidwa firiji popanda kuwonongeka.Chonde ikani ndikusunga mukangolandira.
Ndi mavuto ati omwe ayenera kutsatiridwa posungirako?
Peptide yomwe mudalandira idayikidwa mu ufa wa lyophilized.Ma peptides ndi hydrophilic, ndipo kuyamwa kwa madzi kumachepetsa kukhazikika kwa peptide ndikuchepetsa zomwe zili ndi peptide.Chonde tcherani khutu ku izi: choyamba, ndi desiccants, zosungidwa pamalo owuma.Chachiwiri, kamodzi analandira, chonde yomweyo kuika mu mufiriji -20℃kusungirako, kuti mukhalebe okhazikika kwambiri.Chachitatu, pewani kugwiritsa ntchito mufiriji wopanda chisanu.Kusintha kwa chinyezi ndi kutentha kumatha kukhudza kukhazikika kwa ma peptides.Chachinayi, kutentha kwakunja panthawi yoyendetsa sikukhudza kutsimikizika ndi khalidwe la peptides.
Kodi ndimasunga bwanji ma peptide owumitsidwa ndikalandira malonda?
Mukachilandira, muyenera kuchisunga nthawi yomweyo pa -20° C kapena pansi.
Ngati peptide ili 80%, 20% ina ndi chiyani?
Mchere ndi madzi
Ngati peptide ndi 98% yoyera, 2% ndi chiyani?
Awiri peresenti ya zolembazo zinadulidwa kapena kuchotsedwa zidutswa zotsatizana.
Kodi AMU unit ndi chiyani?
AMU ndi gawo la micropolymerization.Ichi ndiye muyeso wamba wa peptides.