GLP-1(9-37) /GT Peptide/Peptide Supplier

Kufotokozera

GLP-1 (7-37, kapena 7-36amide) ndi mahomoni a insulinotropic omwe amapangidwa mwachangu ndi dipeptidyl peptidase-IV (DPP-IV) kupanga.GLP-1(9-37).Umboni waposachedwa ukuwonetsa kuti GLP-1 (9-37) ili ndi insulinomimetic zotsatira mwa anthu.Izi zimathandizidwa ndi maphunziro azachipatala omwe akuwonetsa kuti kuwongolera kwa GLP-1 mwa anthu (9-37) kumachepetsa shuga wa postprandial mosatengera kutulutsa kwa insulin komanso kuyankha kwa insulin.Tidayerekeza kuti zotsatira za extrapancreatic zotsitsa shuga za GLP-1 (9-37) zimatheka chifukwa choletsa hepatic gluconeogenesis.Tidapanga mapuloteni ophatikiza a GLP-1 pophatikiza GLP-1 (9-37 kapena 7-37) ndi zidutswa za IgG2 Fc za anthu (9-37/Fc, 7-37/Fc).

Zofotokozera

Maonekedwe: ufa woyera mpaka woyera

Kuyera (HPLC):≥98.0%

Kusayera Kumodzi:≤2.0%

Acetate Content(HPLC): 5.0%～12.0%

M'madzi (Karl Fischer):≤10.0%

Zinthu za Peptide:≥80.0%

Kupaka ndi Kutumiza: Kutentha kochepa, kulongedza kwa vacuum, kulondola kwa mg ngati pakufunika.

Mungayitanitsa Bwanji?

1. Contact us directly by phone or email: +86-13735575465, sales1@gotopbio.com.

2. Kuitanitsa pa intaneti.Chonde lembani fomu yoyitanitsa pa intaneti.

3. Perekani dzina la peptide, CAS No. kapena kutsatizana, chiyero ndi kusinthidwa ngati kuli kofunikira, kuchuluka kwake, ndi zina zotero.

4. Order conformation ndi mgwirizano wamalonda wosainidwa bwino ndi NDA (mgwirizano wosawululira) kapena mgwirizano wachinsinsi.

5. Tidzasintha mosalekeza momwe madongosolo akuyendera munthawi yake.

6. Peptide yoperekedwa ndi DHL, Fedex kapena ena, ndi HPLC, MS, COA idzaperekedwa pamodzi ndi katundu.

7. Ndondomeko yobwezera ndalama idzatsatiridwa ngati pali kusiyana kulikonse kwa khalidwe lathu kapena ntchito yathu.

8. Pambuyo pogulitsa ntchito: Ngati makasitomala athu ali ndi mafunso okhudza peptide yathu panthawi yoyesera, chonde muzimasuka kutilankhulana nafe ndipo tidzayankha posachedwa.

Zogulitsa zonse zamakampani zimangogwiritsidwa ntchito pazofufuza zasayansi, izo'ndizoletsedwa kugwiritsidwa ntchito mwachindunji ndi munthu aliyense pathupi la munthu.

FAQ:

Kodi ma peptides omwe anali ndi Cys adachepetsedwa asanatumizidwe?

Ngati peptide sinapezeke kuti ndi oxidized, nthawi zambiri sitimachepetsa Cys.Ma polypeptides onse amatengedwa kuchokera kuzinthu zopanda pake zotsukidwa ndi lyophilized pansi pa pH2 zinthu, zomwe mwina zimalepheretsa makutidwe ndi okosijeni a Cys.Ma Peptides okhala ndi Cys amayeretsedwa pa pH2 pokhapokha ngati pali chifukwa china choyeretsera pH6.8.Ngati kuyeretsedwa kukuchitika pa pH6.8, mankhwala oyeretsedwa ayenera kuthandizidwa ndi asidi mwamsanga kuti ateteze oxidation.Mu gawo lomaliza loyang'anira khalidwe, ma peptides omwe ali ndi Cys, ngati kupezeka kwa molekyulu yolemera (2P + H) ikupezeka pa mapu a MS, zimasonyeza kuti dimer yapangidwa.Ngati palibe vuto ndi MS ndi HPLC, tidzakhala lyophilize mwachindunji ndikutumiza katunduyo popanda kukonzanso kwina.Zindikirani kuti ma peptides okhala ndi ma Cys amalowetsedwa pang'onopang'ono pakapita nthawi, ndipo kuchuluka kwa okosijeni kumadalira kalozera wa peptide ndi momwe amasungira.

Kodi mungadziwe bwanji ngati peptide yatsekedwa?

Timagwiritsa ntchito machitidwe a Ellman kuyesa ngati kupanga mphete kwatha.Ngati mayeso a Ellman ali abwino (achikasu), kamvekedwe ka ring ndi chosakwanira.Ngati zotsatira za mayeso zili zosonyeza kuti alibe (osati achikasu), kuyankha kwa mphete kwatha.Sitimapereka lipoti la kusanthula kwa chizindikiritso cha cyclization kwa makasitomala athu.Nthawi zambiri, padzakhala kufotokozera kwa zotsatira za mayeso a Ellman mu lipoti la QC.

Ndikufuna cyclic peptide, yomwe ili ndi tryptophan, kodi idzakhala oxidized?

Kutsekemera kwa tryptophan ndi chinthu chodziwika bwino mu peptide oxidation, ndipo ma peptides nthawi zambiri amayendetsa njinga asanayeretsedwe.Ngati oxidation ya tryptophan ichitika, nthawi yosungira peptide pagawo la HPLC isintha, ndipo okosijeniyo imatha kuchotsedwa ndikuyeretsedwa.Kuphatikiza apo, ma peptides okhala ndi okosijeni amathanso kuzindikirika ndi MS.

Kodi ndikofunikira kuyika kusiyana pakati pa peptide ndi utoto?

Ngati mulumikiza molekyulu yayikulu (monga utoto) ku peptide, ndikwabwino kuyika danga pakati pa peptide ndi ligand kuti muchepetse kusokoneza cholandilira popinda peptide yokha kapena kupindika mgwirizano wake.Ena safuna nthawi.Mwachitsanzo, popinda mapulotini, n’zotheka kudziwa kuti mbali ina ya amino acid ili patali bwanji polumikiza utoto wa fulorosenti pamalo enaake.

Ngati mukufuna kusintha biotin pa N terminal, kodi muyenera kuyika kusiyana pakati pa biotin ndi ma peptide sequence?

Njira yodziwika bwino yolembera zolemba za biotin yomwe kampani yathu imagwiritsa ntchito ndikulumikiza Ahx ku unyolo wa peptide, ndikutsatiridwa ndi biotin.Ahx ndi 6-carbon compound yomwe imakhala ngati chotchinga pakati pa peptide ndi biotin.

Kodi mungapereke upangiri pa kapangidwe ka phosphorylated peptides?

Pamene kutalika kumawonjezeka, mphamvu yomangiriza imachepa pang'onopang'ono kuchokera ku phosphorylated amino acid kupita mtsogolo.Mayendedwe a kaphatikizidwe amachokera ku C terminal kupita ku N terminal.Ndikofunikira kuti zotsalira pambuyo pa phosphorylated amino acid zisapitirire 10, ndiye kuti, kuchuluka kwa zotsalira za amino acid pamaso pa phosphorylated amino acid kuchokera ku N terminal kupita ku C terminal zisapitirire 10.

Chifukwa chiyani n-terminal acetylation ndi C-terminal amidation?

Zosinthazi zimalepheretsa peptide kuti isawonongeke komanso kulola peptide kutengera momwe idayambira magulu a alpha amino ndi carboxyl mu mapuloteni a makolo.