Kudziwa Elamipretide (736992-21-5)

Zambiri Zoyambira

Elamipretide (CAS No.: 736992-21-5) ndi tetrapeptide yaing'ono ya mitochondria, yomwe imadziwikanso kuti SS-31 ndi MTP-131. Mapangidwe ake a molekyulu ndi C₃₂H₄₉N₉O₅ yokhala ndi molekyulu yolemera 639.79. Chifukwa cha machitidwe ake apadera, yakhala molekyulu ya hotspot pakufufuza kwa matenda okhudzana ndi kusagwira bwino ntchito kwa mitochondrial. Monga "mphamvu" ya maselo, kukanika kwa mitochondrial kumagwirizana kwambiri ndi ukalamba, matenda osowa komanso matenda osiyanasiyana. Mtengo wapakati waElamipretide yagona pakulunjika kwake kwa nembanemba yamkati ya mitochondrial kuti ikonze vuto la mitochondrial.

Njira Yochitira

Kachitidwe kake kamagwira ntchito makamaka pa cardiolipin, phospholipid yofunika kwambiri mu nembanemba yamkati ya mitochondrial. Imatha kumangirira ku cardiolipin yowonongeka, kukhazikika kwa nembanemba yamkati ya mitochondrial, kulimbikitsa kusonkhana kwa ma chain chain complexes, kupititsa patsogolo mphamvu ya okosijeni phosphorylation, kuchepetsa kupanga kwa mitundu yogwira ntchito ya okosijeni (ROS), ndikuletsa kuzungulira koyipa kwa "mitochondrial damage-oxidative stress". Maphunziro oyenerera atsimikizira zimenezoElamipretide imatha kusintha kagayidwe ka mphamvu ya mitochondrial ndikukhala ndi zotsatira zoteteza mumitundu yosiyanasiyana ya matenda.

Kupita patsogolo kwachipatala

Mu kafukufuku wazachipatala, gawo Ⅱ/Ⅲ mayeso azachipatala a Bartter syndrome (matenda osowa a mitochondrial genetic) adawonetsa kuti pambuyo pa milungu 36 ya chithandizo ndi 40 mgElamipretide tsiku ndi tsiku, mtunda woyenda wa mphindi 6 wa odwala unawonjezeka kwambiri ndipo zizindikiro za zizindikiro zinasintha modabwitsa. Mu gawo Ⅱ mayesero okhudzana ndi zaka zowonongeka kwa macular, ngakhale kuti sanafike pamapeto oyambirira, adachepetsa kuchepa kwa ellipsoid zone yokhudzana ndi kuwonongeka kwa photoreceptor, kupereka chitsogozo cha kafukufuku wotsatira.