Penicillin anali antibayotikin yoyamba yomwe imagwiritsidwa ntchito pochita masewera olimbitsa thupi. Pambuyo pa kukula kwa zaka zambiri, maantibayotiki ambiri ayamba, koma vuto la kukana mankhwala obwera chifukwa cha kugwiritsa ntchito maantibayotiki atakula.
Ma Pepticker Peptides amawerengedwa kuti ali ndi chiyembekezo chogwiritsira ntchito ntchito ya antibacterial kanthu, antibacterial ntchito yawo, mitundu yosiyanasiyana, yosakaniza yosiyanasiyana, komanso kukana kotsika mu chandamale. Pakadali pano, ma antibicbiarial ambiri ali mu kafukufuku wa matenda azachipatala, omwe amatsenga (xenopus Laevis anticticrobial peptide) adalowa muyeso wa matenda.
Makina ofotokozedwa bwino
Ma Pepticker Peptides (amps) ndi polypeptives oyambira ndi olemera a 20000 ndikukhala ndi antibacterial zochita. Pakati ~ 7000 ndikupangidwa ndi 20 mpaka 60 amino atsalira. Ma Peptudel ambiri omwe ali ndi mawonekedwe amphamvu amphamvu, kukhazikika kwa kutentha, komanso antibactem schoacterial.
Kutengera kapangidwe kake, ma antimicbiobial ma antides amatha kugawidwa m'magulu anayi: hercial, pepala, lotalika, ndi mphete. Ma pepticrobial mapepu ena amakhala ndi helix imodzi kapena pepala limodzi, pomwe ena amakhala ndi malo ovuta kwambiri.
Njira yodziwika bwino yochitira mankhwala antimicrobial Peptide ndi kuti ali ndi zochitika mwachindunji motsutsana ndi ma cell a mabakiteriya. Mwachidule, ma anticticbichial amasokoneza momwe ma bakinerial amathera, asintha ma membala, kutulutsa metabolites, ndipo pamapeto pake amatsogolera kufalitsa bakiteriya. Chikhalidwe chovomerezeka cha ma antimicrobial mapepu amathandizira kuti azitha kulumikizana ndi ma cell a mabakiteriya. Ma Pepticrobial ma peptidel ambiri amakhala ndi ngongole yabwino ndipo akuti amatchedwa catific antimicrobial mapepu. Kulumikizana kwamagetsi pakati pa catamicbiar ma peptides ndi inionic bacrasirial membrasies kumalimbikitsa kulimbikira kwa antimicricrobial makonda a bakirasi.
Kutulutsa njira zochizira
Kutha kwa ma antificbiobiel ma peptides kuti muchitepo machitidwe angapo ndi njira zosiyanasiyana sizimangowonjezera ntchito za anticticbobial komanso zimachepetsa kuchuluka kwa kukana. Kuchita ma njira zingapo, kuthekera kwa mabakiteriya omwe amapeza masinthidwe ambiri nthawi imodzi kumachepetsedwa kwambiri, kupatsa antimickicrobial zomwe angathe kukana. In addition, because many antimicrobial peptides act on bacterial cell membrane sites, bacteria must completely redesign the structure of the cell membrane to mutate, and it takes a long time for multiple mutations to occur. Ndizofala kwambiri ku khansa chemotherapy kuti muchepetse chotupa ndi kukana mankhwala pogwiritsa ntchito njira zingapo ndi othandizira osiyanasiyana.
Chiyembekezo chazachipatala ndichabwino
Khalani ndi mankhwala a antimicrobial atsopano kuti apewe mavuto otsatira antinticrobial. Chiwerengero chachikulu cha ma antimicrobial mapepu akukumana ndi mayesero azachipatala ndikuwonetsa kuthekera kwachipatala. Ntchito zambiri zimachitikabe pantimicrobial yamakiti monga mantimicrobial othandizira. Ambiri antimicrobial ma peptides ambiri ochiritsa sangathe kubweretsedwa pamsika chifukwa cha kapangidwe kake koyesedwa kapena kusowa kwa kuvomerezeka. Chifukwa chake, kafukufuku wambiri pa kulumikizana kwa zingwe zosokoneza boti ndi malo ovuta kwa anthu kungakhale kothandiza kuti athe kuwunika kuthekera kwa mankhwalawa.
Inde, mankhwala ambiri mu mayesero azachipatala asinthasintha mankhwala ena kuti azisintha zinthu zawo. Pazochitika, kugwiritsa ntchito mabulosi apamwamba a digito ndi chitukuko cha pulogalamu yotsatira kungathandizenso kafukufukuyu ndi chitukuko cha mankhwalawa.
Ngakhale kapangidwe ka antimicrobial Peptives ndi ntchito yabwino, tiyenera kuyesetsa kuchepetsa kukana kwa antimicrobial othandizira. Kupitiliza kukula kwa othandizira antimicrobial othandizira ndi mantimicrobial njirazi kungathandize kuchepetsa mphamvu ya antibayotiki. Kuphatikiza apo, pomwe antibacti yest amavala pamsika, kuwunikira mwatsatanetsatane ndi kasamalidwe kumafunikira kuchepetsa ntchito zosafunikira zothandizira antibacterial momwe mungathere.
Post Nthawi: 2025-07-02