Kodi antimicrobial peptide Omiganan imathanso kukwaniritsa zotsatira za antibacterial

English: Omiganan

English: Omiganan

Nambala ya CAS: 204248-78-2

Fomula ya maselo: C₉₀H₁₂₇N₂₇O₁₂

Kulemera kwa molekyulu: 1779.15

Kutsata: ILRWPWWPWRRK-NH2

Maonekedwe: ufa woyera kapena woyera wa ufa

Momwe Omiganan amachitira:

Ndi peptide yaying'ono kwambiri motero ndizovuta kuzindikira ndikulemba za proteinolysis;Imayendetsedwa ndi C terminus kuti ipitirire kukana proteolysis ndikuchotsa zoyipa za gulu la carboxyl.Ndi amphiphilic ndipo imatha kuyanjana kwambiri ndi nembanemba ya cell.Ma cell membrane akuyembekezeka kukhala chimodzi mwazofuna zawo zazikulu.Ndi polycation yomwe imakonda kuyanjana kwawo ndi nembanemba ya bakiteriya yoyipa komanso zomeric kunja kwa lipopolysaccharide (LPS) yokhala ndi nembanemba ya mammalian osati ndi peptidoglycan.Mu mabakiteriya, kuthekera kwa nembanemba kumakhala koyipa kwambiri kuposa m'maselo amtundu wa mammalian, omwe angapangitse kuti maantibayotiki amange ndikusuntha.Chomaliza ndi vuto lachipatala lomwe antiinflammatory cytidine ilinso ndi ntchito pa erythrocytes, pomwe Omiganan akuwoneka kuti alibe hemolytic.Monga tafotokozera pamwambapa, zotsalira za omiga-nan zili pafupi ndi terminal iliyonse, kutali ndi dera lapakati la hydrophobic la peptide, ndipo chiwerengero chabwino cha peptide chikuwonjezeka kuchokera ku 4+ mpaka 5+, chomwe chingathe kufotokozedwa ndi kuchepa kwa hemolysis. , popeza kusintha kumeneku sikokomera zinthu zonga ma peptide zolumikizidwa ndi nembanemba ya zwitt-rionic mammalian.Izi zimatsimikiziridwa ndi zotsatira za Staubitz ndi ena, kumene chigawo chapakati cha cetin chosungidwa choletsa kutupa mu omiganan chikugwirizana ndi ntchito, pamene chidutswa chomaliza chikuwoneka kuti chikusintha zomwe mukufuna.

Omiganan amagwiritsidwa ntchito:

Omiganan ndi buku la synthetic cationic antimicrobial peptide lomwe likupangidwa kuti lipewe matenda okhudzana ndi catheter komanso kuchiza ziphuphu ndi rosacea.Mu kafukufukuyu, tidawunika mphamvu yakugwiritsa ntchito gel omiganan pamutu pamitundu iwiri yoyika pakhungu (pakhungu la nkhumba la vivo komanso pakhungu la nkhumba la vivo).omiganan0 inayesedwa mu chitsanzo cha ex vivo porcine khungu la colonization 1 mpaka 2% ya gel wothandizira adawonetsa mphamvu yodalira mlingo motsutsana ndi mabakiteriya a Gram-positive ndi Gram-negative ndi yisiti, ndi zotsatira zazikulu zomwe zimawonedwa pakati pa 1 ndi 2%.Panalibe kusiyana kwakukulu pazochitika pakati pa methicillin-resistant ndi Staphylococcus aureus, ndipo ntchito ya mankhwala sinakhudzidwe ndi kukula kwa chinthu chojambulidwa.Gelisi ya Omiganan1% inali ndi ntchito yofulumira yolimbana ndi tizilombo toyambitsa matenda, ndi kuchepetsa 2.7log (10) m'magulu opanga magulu a Staphylococcus epidermolis/site pa 1 h ndi kuchepetsa 5.2log (10) mu flagella / site pa 24 h pambuyo pa ntchito.Mphamvu yamphamvu ya antibacterial ndi antifungal ya gel ya Omiganan1% idatsimikiziridwa ndi maphunziro ena amtundu wa dolphin colonization.Mwachidule, ma gels a Omiganem awonetsedwa kuti ali ndi bactericidal ndi bactericidal zotsatira zomveka bwino zomwe zimadalira mlingo pamitundu yambiri ya tizilombo toyambitsa matenda.Zotsatirazi zikuwonetsanso kuthekera kwa mankhwalawa ngati antimicrobial agent.