Kodi trifluoroacetyl tripeptide-2 ichedwetsa kukalamba?

Zambiri zaife:

Peptide ndi mndandanda wa ma amino acid omwe amalumikizidwa ndi ma peptide.Ma peptides amakhudzidwa kwambiri ndi kayendetsedwe ka mapuloteni, angiogenesis, kuchuluka kwa maselo, melanogenesis, kusamuka kwa maselo, ndi kutupa.Ma peptides a bioactive akhala akugwiritsidwa ntchito kwambiri m'makampani azodzikongoletsera m'zaka zaposachedwa.Ma peptides amafunikira kulemera kochepa kwa maselo (> 500 Da), kuti achepetse kufalikira kwa peptide pakati pa zigawo za epidermal, kukhazikika kwakukulu komanso kusungunuka.Kwa zaka zambiri, gulu la asayansi lapanga kachidutswa kakang'ono kokhazikika ka peptide komwe kamayambitsa kupanga kolajeni ndikuchepetsa makwinya amaso ndi mtundu wa pigmentation.Trifluoroacetyl tripeptide-2 (zotsatizana: TFA-Val-Try-Val-OH) tripeptide synthesis, yopangidwa ngati matrix metalloproteinase ndi elastase inhibitor.Maphunziro a in vitro okhudza chitetezo cha ECM pogwiritsa ntchito trifluoro-acetyl tripeptide 2(TT2), kaphatikizidwe ka proteoglycan m'maselo a cell-matrix, ndi zotsatira za kaphatikizidwe ka progerin mu fibroblasts okhwima aumunthu okhwima adziwika posachedwapa ngati othandizira ma cell. kukhalapo.Zotsatira zikuwonetsa kuti trifluoroacetyl tripeptide 2 ili ndi mitundu yambiri ya anti-kukalamba.Izi zimachepetsa kaphatikizidwe ka progerin, kumawonjezera kupanga kwa proteoglycan, ndikuchepetsa kolajeni, motero kumachepetsa makwinya ndikuwongolera kuuma kwa minofu.Kuphatikiza apo, zotsutsana ndi makwinya, zolendewera zolendewera komanso zomangitsa khungu zidawunikidwa m'maphunziro awiri amaso a in vitro.Trifluoroacetyl tripeptide 2 yawonetsedwa kuti imakhudza pang'onopang'ono makwinya, kulimba, kukhazikika, komanso kugwa.

Kodi trifluoroacetyl tripeptide-2 ichedwetsa kukalamba?

Kafukufuku wasonyeza kuti ma cell senescence amagwirizana kwambiri ndi Progerin.Ndi ukalamba, presenilin imadziunjikira mochulukira m'thupi, zomwe zimapangitsa kuwonongeka kwa nyukiliya ndi kuwonongeka kwa DNA, zomwe zimapangitsa kuti pakhale kukalamba kwapakhungu.Trifluoroacetyl tripeptide-2 ndi tripeptide yogwira ya Elafin, yochokera ku elastase inhibitor.Amachepetsa kaphatikizidwe ka Progerin ndikuwongolera kufooka kwa khungu, kugwa komanso makwinya.

Njira

1. Letsani kaphatikizidwe ka Progerin kuti muchedwetse ma cell a senescence.

2. Limbikitsani kupanga syndecan ndi kutalikitsa moyo wa maselo.

3. Kuletsa ntchito ya matrix metalloproteinases MMP1, MMP3 ndi MMP9, kuchepetsa kuwonongeka kwa mapuloteni a extracellular matrix ndikusunga kukhulupirika kwawo.

4. Imalepheretsa ntchito ya elastase, kuchepetsa kuwonongeka kwa elastin, ndikupangitsa khungu kukhala lolimba komanso losalala.

Kugwiritsa ntchito

Ndikoyenera kwa mitundu yonse ya anti-khwinya ndi kukalamba, kukonza firming, anti-photoaging, post-natal and post-sun body care, etc. Iwo akuwonjezeredwa mu gawo lomaliza la zodzoladzola kupanga.