Makampani opanga kukongola akhala akuchita zonse zomwe angathe kuti akwaniritse chikhumbo cha amayi kuti aziwoneka okalamba.M'zaka zaposachedwa, ma peptides otentha omwe amagwiritsidwa ntchito kwambiri m'makampani azodzikongoletsera.Pakali pano, pafupifupi mitundu 50 ya zipangizo zatulutsidwa ndi opanga zodzoladzola otchuka kunja.Chifukwa cha zovuta zomwe zimayambitsa ukalamba, mitundu yosiyanasiyana ya ma peptide okongola imakhala ndi gawo lapadera pamakina osiyanasiyana kuti akwaniritse cholinga chothana ndi makwinya.Lero, tiyeni tiwone ma peptides ndi manambala osiyanasiyana omwe ali pamndandanda wazopangira.
Gulu lachikhalidwe lidagawa ma peptide okongola ndi makina kukhala Signal peptides, Neurotransmitter inhibiting peptides, ndi Carried peptides.
Mmodzi.Signal peptides
Ma signing peptides amalimbikitsa kaphatikizidwe ka mapuloteni a matrix, makamaka kolajeni, komanso amatha kuwonjezera kupanga elastin, hyaluronic acid, glycosaminoglycans, ndi fibronectin.Ma peptides awa amalimbikitsa kaphatikizidwe ka collagen powonjezera zochitika zama cell a stromal, kupangitsa khungu kukhala lotanuka komanso lachinyamata.Zofanana ndi zida zachikhalidwe zolimbana ndi makwinya, monga vitamini C, zotumphukira za vitamini A.Kafukufuku wa P&G wawonetsa kuti palmitoyl pentapeptide-3 imathandizira kupanga kolajeni ndi mapuloteni ena owonjezera a matrix, kuphatikiza elastin ndi fibronectin.Palmitoyl oligopeptides (palmitoyl tripeptide-1) amachitanso chimodzimodzi, chifukwa chake palmitoyl oligopeptides amagwiritsidwa ntchito kwambiri.Palmitoyl pentapeptide-3, palmitoyl tripeptide-1, palmitoyl hexapeptide, palmitoyl tripeptide-5, hexapeptide-9 ndi nutmeg pentapeptide-11, zomwe zimagulitsidwa kwambiri pamsika, ndi ma peptides amawu.
Awiri.Neurotransmitter peptides
Peptide iyi ndi njira yofanana ndi botoxin.Imalepheretsa kaphatikizidwe ka SNARE receptor, imalepheretsa kutulutsa kwapakhungu kwa acetycholine, kumatchinga chidziwitso cha kufalikira kwa mitsempha ya mitsempha, komanso kumasula minofu ya nkhope kuti itonthoze mizere yabwino.Ma peptideswa amagwiritsidwa ntchito kwambiri ngati ma peptides owonetsa ndipo ndi oyenera kugwiritsidwa ntchito m'malo omwe minofu yofotokozera imakhazikika (kumakona a maso, nkhope, ndi mphumi).Zoyimira za peptide ndi: acetyl hexapeptide-3, acetyl octapeptide-1, pentapeptide-3, dipeptide ophiotoxin ndi pentapeptide-3, yomwe imagwiritsidwa ntchito kwambiri ndi acetyl hexapeptide-3.
Atatu.Ma peptides onyamula
Ma tripeptides (Gly-L-His-L-Ls(GHK)) mu plasma yaumunthu ali ndi chiyanjano cholimba ndi ayoni amkuwa, omwe amatha kupanga peptide yamkuwa yovuta (GHK-Cu).Chotsitsa chamkuwa ndi gawo lofunikira pakuchiritsa mabala komanso njira zambiri za enzymatic reaction.Kafukufuku wasonyeza kuti GHK-Cu ikhoza kulimbikitsa kukula, kugawanika ndi kusiyanitsa kwa maselo a mitsempha ndi maselo okhudzana ndi chitetezo cha mthupi, ndipo akhoza kulimbikitsa bwino machiritso a mabala ndi kukula kwa majeremusi.Chopangidwa choyimiridwa ndi peptide yamkuwa ndi peptide yamkuwa.
Zinayi.mitundu ina ya peptides
Ntchito yayikulu ya peptide yachikhalidwe ndi yotsutsa makwinya komanso kukalamba kupatula peptide yamkuwa (peptide yamkuwa imakhala ndi zinthu zambiri nthawi imodzi).M'zaka zaposachedwa, mitundu yosiyanasiyana ya ma peptide yakhala ikuchulukirachulukira, ena mwa omwe amakwaniritsa cholinga chothana ndi makwinya ndi kukalamba kuchokera kumakina atsopano komanso momwe amawonera (anti-free radical oxidation, anti-carbonylation, anti-inflammatory, anti - edema ndi kulimbikitsa kukonza khungu).
1. Anti-sagging khungu, kulimbikitsa khungu kulimbikitsa
Palmitoyl dipeptide-5, hexapeptide-8, kapena hexapeptide-10 imalimbitsa khungu polimbikitsa LamininV mtundu wa IV ndi VII kolajeni, pomwe palmitoyl tetrapeptide-7 imachepetsa kupanga kwa interleukin-6 ndikuchepetsa kutupa.Peptide yogwira ntchito iyi ndi chitukuko chogwira ntchito, mitundu yatsopano ikuwonjezeka nthawi zonse, yomwe imagwiritsidwa ntchito kwambiri ndi palm tetrapeptide-7.
2. Glycosylation
Ma peptides awa amatha kuteteza collagen kuti asawonongeke komanso kulumikizana ndi mitundu yokhazikika ya carbonyl (RCS), pomwe ma anti-carbonyl peptides amatha kuwononga ma radicals aulere.Chisamaliro chachikhalidwe chapakhungu chimakhala chofunikira kwambiri ku anti-free radicals, zomwe zimawonekera kwambiri ngati anti-carbonylation.Carnosine, tripeptide-1 ndi dipeptide-4 ndi ma peptides omwe ali ndi ntchito zotere
3. Kupititsa patsogolo edema yamaso, kusintha microcirculation ndi kulimbikitsa kufalikira kwa magazi
Acetyltetrapeptide-5 ndi dipeptide-2 ndi zoletsa zamphamvu za ACE zomwe zimapangitsa kuti magazi aziyenda bwino poletsa kutembenuka kwa angiotensin I kukhala angiotensin II.
4. Limbikitsani kukonza dermal
Palmitoyl hexapeptidde-6, template ya genetic immune peptide, imatha kulimbikitsa kuchulukana kwa fibroblast ndi kulumikizana, kaphatikizidwe ka collagen ndi kusamuka kwa maselo.
Ma peptides omwe ali pamwambapa oletsa kukalamba aphatikiza ambiri aiwo.Kuphatikiza pa ma peptide oletsa kukalamba omwe tawatchulawa, ma peptide ena ambiri odzikongoletsera apangidwa m'makampani, monga kuyera, kukulitsa mabere, kuchepa thupi ndi zina zotero.
Nthawi yotumiza: Mar-22-2023