Dulaglutide, 923950-08-7

Dzinaliulaglutide – solution in PBS/ dulaglutide

Nambala ya CAS: 923950-08-7

Nambala ya kampani:GT-F002

Zotsatira: H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Glu-Gln-Ala-Ala-Lys-Glu-Phe-Ile- Ala-Trp-Leu-Val-Lys-Gly-Gl y-Gly-OH

Njira ya molekyulu: C149H221N37O49

Kulemera kwa molekyulu: 3314.62

Dulaglutide CAS NO.923950-08-7.jpg

Zizindikiro zaukadaulo:

Maonekedwe White ufa
Kuyera (HPLC) kunali ≥95.0%

Heterozygosity imodzi inali yochepera 2.0%

Acetic acid yomwe ili pakati pa 5.0% mpaka 12.0%

Chinyezicho chinali ≤10.0%

Zolemba za peptide zinali ≥80.0%

Kupakira ndi Kutumiza:

Kutentha kochepa, kulongedza vacuum, zolondola mpaka milligram popempha.

Mafotokozedwe Akatundu:

Durraglutide ndi agonist watsopano wa GLP-1R yemwe amagwira ntchito kwa nthawi yayitali, yemwe amachokera ku kuphatikizika kwa ma analogi awiri a DPP-4 inhibitory GLP-1 ndi chidutswa cha immunoglobulin heavy chain IgG4-Fc.Ntchito yake ndi yofanana ndi ya endogenous GLP-1 m'mawonetsedwe azachipatala, yokhala ndi theka la moyo wa masiku 5, ndipo imatha kuchedwetsa kuchotsedwa kwaimpso.A FDA adavomereza dulaglutide kuti agwire jekeseni wa subcutaneous mu September 2014. European Commission inavomereza dulaglutide kuti ijaidwe pansi pa ngozi ku Ulaya mu December 2014.

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