L-carnosine ndi kamolekyu kakang'ono kamene kamakhala ndi mawonekedwe a dipeptide ooneka ngati L omwe amapezeka m'chilengedwe ndipo amapangidwa ndi mapangidwe achilengedwe a dipeptide L omwe amapezeka m'chilengedwe.Dipeptide yopangidwa ndi β-alanine ndi L-histidine.Carnosine ali zosiyanasiyana ma antioxidant, odana ndi ukalamba ndi zokhudza thupi ntchito chisamaliro chaumoyo ndi zotsatira zachipatala, monga matenda oopsa, matenda a mtima, senile cataract, chilonda kuchira, odana ndi chotupa, chitetezo chitsanzo mayeso, odana ndi nkhawa zinthu ndi zina zotero.
Udindo wa
Carnosine ndi carnosine wopezeka ndi wasayansi waku Russia Gulevich pamodzi ndi carnitine.Ku United Kingdom, Korea, Russia, ndi China, kafukufuku wasonyeza kuti carnosine ili ndi mphamvu yowononga antioxidant ndipo imapindulitsa anthu.Carnosine yasonyezedwa kuti imachotsa mitundu yambiri ya okosijeni (ROS) yomwe imapangidwa ndi okosijeni wochuluka wa mafuta acids mu cell membrane panthawi ya kupsinjika kwa okosijeni, komanso α-β unsaturated aldehydes.
Kafukufuku wambiri wapeza kuti N-acetylcarnosine imakhala ndi zotsatira zabwino popewa komanso kuchiza ng'ala.Mmodzi mwa maphunzirowa adawonetsa kuti carnosine adatsitsimutsa ng'ala chifukwa cha mawonekedwe a crystalline opacities mu makoswe oyambitsidwa ndi guanidine.Ngakhale kuti zonenazi zimathandizira mapindu angapo ongopeka m'maso monga chithandizo cha carnotin cha ng'ala, mpaka pano, sichinathandizidwe mokwanira ndi gulu lazachipatala.Mwachitsanzo, a Royal Orthopaedics ankanena kuti carnosine inalibe chitetezo kapena yothandiza pochiza ng'ala.
Malinga ndi lipoti la 2002, carnosine ikhoza kupititsa patsogolo maubwenzi a anthu ndi kuonjezera mawu ogwiritsidwa ntchito ndi ana omwe ali ndi autism, koma kusintha komwe kunanenedwa mu phunziroli kungabwerenso chifukwa cha kusintha, placebo, kapena zinthu zina zomwe sizinalembedwe mu kafukufukuyu.
Njira ya kaphatikizidwe
Pakalipano, njira zopangira carnosine zimakhala ndi zolakwika zina: chifukwa cha kuchepa kwa mbali zomwe zimachitika, mbali iyi imachitika ndi L-histidine imidazole mphete.L-histidine adzazungulira osachepera 0,8% mu anachita ndondomeko, kuchepetsa mankhwala zokolola;Panthawi imodzimodziyo, n'zovuta kupatutsa L-carnosine ndi kuyera koyera koyera kuchokera ku zosakaniza zovulaza (mawonekedwe ake ozungulira, imidazole isomers, ndi zina zotero), zomwe zimakhudza chiyero cha malonda, chifukwa zosakanizazi zimakhala ndi zofanana za physicochemical ndi L-carnosine.Chifukwa cha kupezeka kwa zosakaniza izi, zotsatira za L-carnosine ndi poizoni, osati kukonzekera koyera koyambirira.
Njira yatsopano yopangira L-carnosine ndi motere: phthalic anhydride imagwira β-alanine ndi phthalic anhydride β-phthaloylalanine, chlorinated reagent chlorides phthaloyl-β-phthaloylalanine ku phthaloyl-alanine β-alanyl chloride;L-trialkylsilane protective compound imakhudzidwa ndi trialkylchlorosilane kapena hexahydroxysilane, imagwira ntchito ndi phthalyl β-alanyl chloride condensation ya hydrochloride, imachotsa gulu loteteza ndi mowa wa anhydrous, ndipo imapanga hydrochloride mu alkaline solution kuti ipeze intermediate hydrochlorazites hydrochlorazites, intermediate hydrochlorazite synthesis L-carnosine mu mowa wa anhydrous.Izi mankhwala ndi imidazole mphete pa L-otetezedwa histidine kupewa mavuto a imidazole mphete pa L-histidine ndi zinthu zina, ndi kupeza koyera L-carnosine ndi zotsatira otsika ndi mkulu okwana zokolola ndi okhutira.
Nthawi yotumiza: Oct-24-2023