Izi m'maganizo anticebiobial awa adachokera ku mabungwe azachipatala, zinyama, mipabians, ndi zina zambiri:
. Amadziwika ndi dera lokhazikika la alkaline n-terminal n-terminal lotsatiridwa ndi kachidutswa kakang'ono ka hydrophobic.
2. Xenopus antimicrobial mapepu (Maginainin) amachokera ku minofu ndi m'mimba mwa achule. Kapangidwe ka Xenopus antimicrobial mapepu ankapezekanso kwakukulu, makamaka mu hydrophobic malo okhala. Kusintha kwa Xenopus Antipeptide m'mapidi adaphunzitsidwa ndi N-zolembedwa ndi gawo lolimba la NMR. Kutengera ndi kusintha kwa mankhwala a acylamine, heenopus antipepside kunali malo ofanana, ndipo amatha kuyambiranso kupanga khola la 13mm ndi mawonekedwe a nthawi yayitali a 30mm.
3. Depunsin Deptides amachokera ku polykavalingotic neutrophil kalulu kalulu ndi ma cubule okwanira a nyukiliya ndi ma cell a nyama. Gulu la ma peptides antimicerobial ofanana ndi chitetezo chodzitchinjiriza a ku Lammalian adachotsedwa ku tizilombo, chotchedwa "Depturm Peptudes". Mosiyana ndi njira zodzitchinjiriza za Malmalian, zotetezera tizilombo zimangogwira mtima motsutsana ndi mabakiteriya oyenera. Ngakhale mapepu otetezera tizilombo amakhala ndi zotsalira zisanu ndi chimodzi, koma njira yothetsera mgwirizano wina ndi mnzake ndizosiyana. The intramulecular Disulfider Mode Miniti ya antibacterial mapside omwe amachokera ku Drosophila Melalatophest anali ofanana ndi mtsogoleri wa chomera. Pansi pa maryristal, ma peptides otetezedwa amaperekedwa ngati otsika.
4.tachiyeln amachokera ku nkhanu za nsapato, zotchedwa Horseshoecrab. Kafukufuku wosintha amawonetsa kuti amatenga mawonekedwe a antiparallel b-reaction (3-8 maudindo, 11-16 maudindo), momwe b-Angle amalumikizidwa wina ndi mnzake (8-11 maudindo), ndipo zomangira ziwiri zokhumudwitsa zimapangidwa pakati pa magawo 7 ndi 12, ndipo pakati pa 3 ndi 16 udindo. Mu kapangidwe kake, hydrophobic amino acid ali mbali imodzi ya ndege, ndipo zotsalira zisanu ndi chimodzi zimawonekera mchira wa molekyulu, kotero mawonekedwewo alinso biophilic.
Zikuchitika kuti pafupifupi ma Peptives onse antimicrobial mulingic mwachilengedwe, ngakhale amasiyanasiyana kutalika ndi kutalika; Kumapeto kwenikweni, kaya mwa mawonekedwe a alpha kapena b-Mundung, mawonekedwe a biopicific ndiye chinthu chomwe chimachitika.
Post Nthawi: 2025-07-03