Ma peptides antimicrobial awa adachokera ku chitetezo cha tizilombo, nyama zoyamwitsa, amphibians, ndi zina zambiri, ndipo makamaka akuphatikizapo magulu anayi:
1. cecropin poyamba analipo mu lymph lymph ya Cecropiamoth, yomwe imapezeka makamaka mu tizilombo tina, ndipo ma peptides ofanana ndi bactericidal amapezekanso m'matumbo a nkhumba.Amadziwika ndi dera la alkaline la N-terminal lotsatiridwa ndi chidutswa chachitali cha hydrophobic.
2. Xenopus antimicrobial peptides (magainin) amachokera ku minofu ndi m'mimba mwa achule.Mapangidwe a xenopus antimicrobial peptides adapezekanso kuti ndi helical, makamaka m'malo a hydrophobic.Kukonzekera kwa ma xenopus antipeptides mu zigawo za lipid kunaphunziridwa ndi N-yotchedwa NMR yolimba-gawo.Kutengera ndi kusintha kwamankhwala kwa acylamine resonance, ma helice a xenopus antipeptides anali malo ofananirako, ndipo amatha kusinthana kupanga khola la 13mm lokhala ndi helical ya 30mm nthawi ndi nthawi.
3. Defensin Defense peptides amachokera ku polykaryotic neutrophil rabbit polymacrophages yokhala ndi nyukiliya lobule ndi maselo am'mimba a nyama.Gulu la ma peptide oletsa tizilombo toyambitsa matenda ofanana ndi ma peptides oteteza mammalian adachotsedwa ku tizilombo, zotchedwa "insect defense peptides".Mosiyana ndi ma peptides oteteza tizilombo, ma peptides oteteza tizilombo amagwira ntchito motsutsana ndi mabakiteriya a Gram-positive.Ngakhale ma peptides oteteza tizilombo amakhala ndi zotsalira zisanu ndi chimodzi za Cys, koma njira ya disulfide yolumikizana wina ndi mnzake ndi yosiyana.Njira yomangira mlatho wa intramolecular disulfide ya antibacterial peptides yotengedwa ku Drosophila melanogast inali yofanana ndi ma peptides oteteza mbewu.Pansi pa mikhalidwe ya kristalo, ma peptide oteteza amawonetsedwa ngati dimers.
4.Tachyplesin amachokera ku nkhanu za akavalo, zomwe zimatchedwa horseshoecrab.Kafufuzidwe kasinthidwe zikusonyeza kuti utenga antiparallel B-kupinda kasinthidwe (3-8 malo, 11-16 malo), mmeneβ-ngodya imalumikizidwa wina ndi mnzake (maudindo 8-11), ndipo zomangira ziwiri za disulfide zimapangidwa pakati pa 7 ndi 12 malo, komanso pakati pa 3 ndi 16 malo.Mu kapangidwe kameneka, hydrophobic amino acid ili mbali imodzi ya ndege, ndipo zotsalira zisanu ndi chimodzi za cationic zimawonekera pa mchira wa molekyulu, motero kapangidwe kake ndi biophilic.
Izi zimatsatira kuti pafupifupi ma peptide onse oletsa tizilombo toyambitsa matenda ndi cationic mu chilengedwe, ngakhale amasiyana kutalika ndi kutalika;Pamapeto apamwamba, kaya mu mawonekedwe a alpha-helical kapenaβ-kupinda, kapangidwe ka bitropic ndi chinthu chofala.
Nthawi yotumiza: Apr-20-2023