Maukadaulo a Glycopkhoptide

Malinga ndi njira yolumikiza ya amino acid ndi shuga, shupyala peptside imatha kugawidwa m'magulu anayi:

1. N-Glycosylation glycopmetides ali ndi shuga otsika kumapeto kwa ascan unyolo wa Glycan zopangidwa ndi zotsalira. Shuga ndi n-acetylglusamine.

N-Glycosuslation adasinthidwa zojambula glycopkhoptide

2. Kapangidwe ka O-Glycosity ndi losavuta kuposa n-glycosity. Glycopkhophy iyi imakhala yofupikira kwambiri kuposa glycan, koma ili ndi mitundu yambiri kuposa n-glycosyty. Serring ndi Pasana nthawi zambiri amakhala glycosyy mu peptide unyolo. Kuphatikiza apo, pali glycoptides okongoletsedwa ndi tyrosine, hydroxyl, ndi hydroxypline glycoslation. Ulalo wolumikizira ndi ma hydroxyl oxygen atomu mbali imodzi ya zotsalira. Ma sugar olumikizidwa ndi galactose kapena n-acetygalactine (gal & galnac) kapena glucosam / glucosac (mannose), mannac), et.

O-Glycoslationtion amasintha kapangidwe kake

3. Glycopkhoptide o-glcnac glycosusty ((n-acetylcytetion (Noc)) (glcnacn-acetylglucosamine / acetylglucosamine)

Chimodzi mwa n-acetylglucosamine (glcnac) glycosylation imalumikizana ndi mapuloteni o-glcnac ku ma hydroxyl oxygen atomu kapena otsalira otsalira. O-glcna glycosyhlation ndi o-glcnac monosaccharide chokongoletsera popanda glycan; Monga Phopside phossorylation, o-glcnac glycosysslation ya glycopterides ndi yopanga mapulojekiti amphamvu kwambiri. Zokongoletsera za o-glcnac zimatha kuyambitsa matenda osiyanasiyana monga matenda ashuga, matenda amtima, zotupa, matenda a Alzheimer ndi otero.

Malangizo a Glycosylation of Glycoptetions

Zojambula zazikulu za polypeptide ndi shuga zimalumikizidwa ndi unyolo mapuloteni, ndipo masamba omwe akulumikiza unyolo, amatchedwa masamba a glycosyty. Popeza kulibe template kuti atsatire ma bisyynthesis a shuga a glycopkhoptide shufu, ma unyolo osiyanasiyana adzalumikizidwa pamalo omwewo a Glycosty, omwe amatsogolera ku microscopic Nohongogeneity.

Glycosylation ya glycopmetides

1. Mphamvu ya glycoptide glycosytion pa mankhwala - kufunikira kwa mapuloteni achire

Pankhani ya mapuloteni othandizira, glycosylation imakhudzanso theka la moyo ndi kulowera mapuloteni mankhwala ku Vivo

2. Soluble Glycoptide Glycosylation ndi mapuloteni

Kafukufuku wawonetsa kuti unyolo wa shuga pamtunda wa mapuloteni amatha kusintha molecular soubini ya mapuloteni

3. Glycopkhoptide Glycosylation ndi Protein Imnogenicity

Kumbali ina, maunyolo a shuga padziko lapansi amatha kuchititsa mayankho amthupi. Kumbali inayo, maunyolo a shuga amatha kuphimba malo ena pa mapuloteni pansi ndikuchepetsa immunogenicity

4. Glycopkhoptide Glycosyty yomwe imawonjezera kukhazikika kwa mapuloteni

Glycosylation imatha kuwonjezera kukhazikika kwa mapuloteni osiyanasiyana (monga ma rencutonts, kutentha, etc.) ndikupewa kuphatikizika kwa mapuloteni. Nthawi yomweyo, maunyolo a shuga padziko lapansi amathanso kuphimba ma proteruc deteruction a mamolekyu a mapuloteni, potero akuwonjezera kukana kwa mapuloteni a proteases

5. glycoptide glycosyty yomwe imakhudza zochitika zachilengedwe za mamolekyulu a mapuloteni

Kusintha mapuloteni glycosylation kumathanso kuthandizanso mamolekyulu a protein kuti apange zochitika zatsopano zachilengedwe