Peptides amagwiritsidwa ntchito kwambiri m'makampani opanga mankhwala, zopangira, utoto ndi minda ina. Kusungunuka kwa ma peptides ndi chinthu chofunikira chokhudza kupambana kapena kulephera kwa zoyeserera kwa labotale.
Nthawi zambiri, kusungunuka kwa ma peptides kumagwirizana kwambiri ndi amino acid mndandanda wa peputirani unyolo wonse. Pamene gawo lonse la acidic limakhala lovuta kusungunuka, ndikofunikira kuwonjezera njira yoyenera ya alkalinine, ndipo pamene alkaline peptide ndizovuta kusungunuka, ndikofunikira kuwonjezera njira yoyenera yacidic. Pamene mndandandawo uli ndi mitundu ya hydrophobic amino acid kapena ndale Acids, sangathe kusungunuka m'madzi nthawi yomweyo, ndipo nthawi zambiri amafunika kuyika pang'ono osungunuka. Mukatha kusungunuka bwino, imachepetsedwa pamadzi ambiri. Ogwiritsa ntchito solton ace osungunuka ndi acetonitrile, DMSO, propropanol, endopropanol, etc. ziyenera kunenedwa kuti utoto wa peptide womwe umakhala ndi maxidation a peptide. Kuphatikiza apo, pofuna kuthandiza makasitomala kusintha ma peptide kuti akwaniritse zoyeserera zabwino, nthawi zambiri timapereka malingaliro ena othandiza pazinthu zathupi, mankhwala opangira mafuta.
Momwe mungakulitsire solubility ya Pepsides
Kusungunuka kwa malo osungunuka bwino kumatha kusintha ndi:
1. Pangani zosintha kwa C ndi n tempni wa matepi a polypeptidide, tikuwonetsa kuti cerpusukili, ndipo pamalingaliro oyambira, tikuwonetsa kuti ndi.
2. Sinthani a amino acid mu kulowetsa mu polypeptide an ydrophobic amino acid acid, monga w, f, ine, y. Pamene hydrophobic amino acid imawoneka mobwerezabwereza kapena mosalekeza komanso mobwerezabwereza, peptide yonseyo nthawi zambiri imakhala yopanda pake, tidzalimbikitsa makasitomala kuti achuluke popanda kusintha zotsatira zake. Kapenanso, kusungunuka kumatha kusintha pochepetsa kuchuluka kwa hydrophobic amino acid.
3. Kusinthanitsa hydrophobic amino okhazikika mu mndandanda: Kusintha ma hydrophobic amino acid okhazikika mu mndandanda wokhala ndi solu acid amatha kusintha kusungunuka. Nthawi zambiri timagwiritsa ntchito gly ndi Ala kuti tisinthe maje hyrophobic amino acids, nthawi zambiri imatha kufooka kokwanira, komwe kumakhalanso kwachikhalidwe koma bwino kusintha kusungunuka kwa nsonga.
Post Nthawi: 2025-07-01