Momwe mungasinthire RGD Cycloptide

Kuphatikiza apo, kapena kuphatikiza, ndi heterodimer kutanthauzira glycoprotein receptor omwe amasungunulira a cell a cell a cell ndi zikwangwani. Imapangidwa a ndi b aboma. Zimakhudzidwa ndi kukhathamiritsa kwa zochita zosiyanasiyana za cell kuphatikiza kusamukira kwa cell, kulowerera kwa maselo, khungu ndi kuperewera kwa cell, zomata za cell, ndi angiogeneisis njira. Kuphatikizapo avb3 Tsopano zikufufuzidwa kwambiri. Mawonekedwe a exrin avb3 imagwirizana kwambiri ndi chotupa chosamuka, angiogeneis, kutupa ndi mafupa. Belrin imafotokozedwa kwambiri pamiziro yonse yotupa ndi endothelial cell a neovascularization. Maonekedwe a Insrin amagwirizana kwambiri ndi chotupa chosamuka ndi angiogeneis. M'zaka zaposachedwa, maphunziro sayansi awonetsa kuti pali zinthu ziwiri zomwe zingayendetse ku Rgd peptide, komwe kumakhala kotsutsa ma peptides to rentin olandila.

Prept Peptide adazilemba mu Linear RGD peptide ndi RGD Cycli Peptide. Poyerekeza ndi chiwonetsero cha RGD peptide, RGD Cyclic Peptide ali ndi mphamvu yolumikizirana ndikulandila. Otsatirawa ndi mitundu yodziwika bwino komanso njira za kaphatikizidwe wa RGD Coptopside.

Mitundu yodziwika ya RGD Cyclictures:

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Kaphatikizidwe wa RGD Cycli Peptide:

Mtundu wothandizira wa RGD peptide pabwalo la a RGD Plapsiis m'munda wa gawo lolimba la gawo la polyteptid synthesis ukadaulo. Njira yatsopanoyo ndikusankha 2-chloro-trichenylhmethyl chloride lormoride ngati gulu loyambirira la DGIME Acids ndi chiwonetsero champhamvu kuti muchotse gulu la Pinoc lopanda Pinoc. Chothandizira chodziwikacho chinawonjezeredwa kuti chichotse gulu la Carboxyl Woteteza a Aspartic a aspartic a acin, omwe amatsatiridwa ndi ma amino Puptic Peptide. Pomaliza, peptiyo ya cyplic imadulidwa mwachindunji kuchokera ku resin ndi njira yodulira.