Njira ya cysteine ​​​​protease action

Njira yochitira

Ma Enzymes ndi mapuloteni omwe amathandizira kusintha kwamankhwala.Enzyme imalumikizana ndi gawo lapansi kuti lisinthe kukhala chomaliza.Zoletsa zimamangirirana wina ndi mnzake kuti gawo lapansi lisalowe m'malo a enzyme ndi/kapena kuletsa enzymeyo kuti isapangitse zomwe zikuchitika.Pali mitundu yambiri ya zoletsa zomwe zimaphatikizapo: zosatchulika, zosasinthika, zosinthika - zopikisana komanso zopanda mpikisano.Ma reversible inhibitors amamangiriza ku ma enzymes omwe ali ndi machitidwe osalumikizana (monga ma hydrophobic interactions, hydrogen ndi ionic bond).Njira zowongolera zosakhazikika zimaphatikizanso kutulutsa gawo la mapuloteni a enzyme ndikupewa zonse zomwe zimachitika mthupi kapena mankhwala.Ma Specific inhibitors amagwira ntchito pa enzyme imodzi.Ziphe zambiri zimagwira ntchito molingana ndi ma enzymes apadera.Competitive inhibitors ndizinthu zonse zomwe zimafanana kwambiri ndi kapangidwe ka mankhwala ndi geometry ya molekyulu ya gawo lapansi.Inhibitor imatha kuyanjana ndi enzyme pamalo omwe akugwira ntchito, koma palibe chomwe chimachitika.Noncopetitive inhibitors ndi zinthu zomwe zimalumikizana ndi ma enzymes koma nthawi zambiri sizimalumikizana pamalo omwe akugwira ntchito.Cholinga cha ukonde wa inhibitor yopanda mpikisano ndikusintha mawonekedwe a enzyme, potero amakhudza malo omwe akugwira ntchito, kotero kuti gawo lapansi silingathenso kuyanjana ndi enzyme kuti igwire.Zoletsa zopanda mpikisano nthawi zambiri zimasinthidwa.Ma Irreversible inhibitors amapanga mgwirizano wolimba ndi ma enzyme.Zina mwa zoletsa izi zimatha kuchitapo kanthu kapena kuzungulira malo omwe akugwira ntchito.

ntchito

Ma enzymes amagwiritsidwa ntchito kwambiri m'mafakitale, monga kutsuka mbale, chakudya ndi mafakitale opangira moŵa.Mapuloteni amagwiritsidwa ntchito mu "microbial" ochapira ufa kuti afulumizitse kuwonongeka kwa mapuloteni mu dothi monga magazi ndi mazira.Kugwiritsa ntchito ma enzymes pamalonda kumaphatikizapo kusungunuka m'madzi, zomwe zimapangitsa kuti zikhale zovuta kuzibwezeretsanso, komanso kuti zinthu zina zomaliza zimalepheretsa ma enzyme (kuwongolera mayankho).

Mamolekyu a mankhwala, mamolekyu ambiri a mankhwala ndi ma enzyme inhibitors, ndipo ma enzyme inhibitors a mankhwala nthawi zambiri amadziwika ndi mawonekedwe awo komanso zotsatira zake.Kukhazikika kwapamwamba komanso zotsatira zake zidawonetsa kuti mankhwalawa anali ndi zovuta zochepa komanso kawopsedwe wochepa.Ma enzyme inhibitors amapezeka m'chilengedwe ndipo amakonzedwa ndikupangidwa ngati gawo laling'ono la pharmacology ndi biochemistry 6.

Ziphe zachilengedwe nthawi zambiri zimakhala zoletsa ma enzyme omwe adasinthika kuti ateteze mitengo kapena nyama zosiyanasiyana kwa adani.Poizoni wachilengedwewa amaphatikizanso mankhwala oopsa kwambiri omwe adapezekapo.