Kufotokozera mwachidule ndi kugwiritsa ntchito cerulein

Mwachidule

Caerulein, yomwe imadziwikanso kuti cerulein, ndi chikopa cha chule cha ku Australia HYlacaerulea chopangidwa ndi 10 amino acid.Ndi molekyulu ya decapeptide yoperekedwa ndi trifluoroacetate yomwe imakhala ngati cholecystokinin analogue pama cell a pancreatic vesicular ndipo imatha kuyambitsa kutulutsa kwa michere yambiri yam'mimba ndi madzi a pancreatic, zomwe zimapangitsa kuti pakhale pachimake edematous kapamba.Cerutin ingagwiritsidwe ntchito pophunzira mapuloteni a Nf-κb up-regulation monga intercellular adhesion molecule-1 (ICAM-1) zokhudzana ndi kutupa monga NADPH oxidase ndi Janus kinase mediated transduction transduction.Zakhala zikugwiritsidwa ntchito bwino kukhazikitsa mitundu ya kapamba wowopsa mu makoswe, mbewa, agalu, ndi ma hamster aku Syria (AP).Madzi a m'mitsempha amaperekedwa bwino kwambiri ndi jekeseni wa mtsempha, dermal, kapena intraperitoneal.Amagwiritsidwa ntchito kwambiri pakuyesa kwachipatala kwa acute edematous pancreatitis, ndipo kuyesa kwa in vitro kumagwiritsidwa ntchito pamitundu yama cell.Kuphatikiza apo, imagwiritsidwa ntchito pakuwunika ntchito ya ndulu.

Kufotokozera mwachidule ndi kugwiritsa ntchito cerulein

Zambiri

Maonekedwe: ufa woyera

Nambala ya CAS: 17650-98-5

Nambala ya Gutuo: GT-F055

Kutsata: pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

Mapangidwe a maselo: C58H73N13O21S2

Kulemera kwa molekyulu: 1352.4

Kusungunuka: Kusungunuka mu 50mM ammonium hydroxide pa ndende ya 1.0mg/ml

Kugwiritsa ntchito

1. Amagwiritsidwa ntchito kwambiri pofanizira acute edematous pancreatitis pamayesero azachipatala.

2. Kugwiritsa ntchito kumitundu yama cell mu vitro.

3. Amagwiritsidwa ntchito poyesa ntchito ya ndulu.

Kupanga chitsanzo cha kafukufuku wa pachimake kapamba pophunzira za cerulein (AP) cell biology, mawonekedwe a pathophysiological ndi mawonetseredwe a matenda a organic pancreatitis pachimake.Kuphatikiza pakufufuza kusintha kwa m'mapapo kwa matenda a AP, kumatha kuwonetsanso bwino kuyanjana kwa visceral endocrine monga mulingo wa metabolin ndi CCK.Ikhoza kugwiritsidwanso ntchito kuyesa kukonzanso ndi kubwezeretsanso minofu yovulala pambuyo pothetsa zinthu zoopsa.

5. Kugwiritsa ntchito Caerulein cerulein (cerulein) ndi LPS kukhazikitsa zitsanzo za kapamba kungapangitse zotsatira za synergistic, zoyambazo zimatha kulimbikitsa ma enzymes a pancreatic kuti awononge kapamba, ndikuyambitsa ma cell otupa mosalekeza kuti amasule zotupa.Pambuyo pake, LPS imasokoneza kuyankhidwa kwanthawi zonse kwa oyimira pakati otupa, motero kupanga kapamba komweko monga chotupa chokhazikika.

6. Cerulein angagwiritsidwe ntchito kuteteza kupweteka kwa ndulu, renal colic, ndi intermittent claudication ululu.Nthawi zambiri imatengedwa ngati mdani wa kephalin.