Mwachidule ndi kugwiritsa ntchito certuren

Kulemeletsa

Caertulein, omwe amadziwikanso kuti Certulein, ndi khungu lochotsa Frantralia la Australia lokhala ndi ma amino acid. Ndi nthochi ya detupeptide yomwe imaperekedwa ndi triffeloacereate kuti imagwira ngati cholecytokinin analogue cells ma cell ancreatic ndipo imatha kuchititsa kuti ma encyreat michere ndi pancreatic. Crutin angagwiritsidwe ntchito pophunzira mapuloni a NF-κB UP-κCLARAL molecule-1 (ICAM-1) monga Nadph Oxidase Oxidase Kutumiza Kosiyanasiyana. Zakhala zikugwiritsidwa ntchito bwino kukhazikitsa mitundu ya pachimake kapamba ku makoswe, mbewa, agalu, ndi harrian hamsters (AP). Madzi am'mimba amathandizidwa kwambiri ndi mtsempha wamkati, ma dermal, kapena intrapendeal. Amagwiritsidwa ntchito kwambiri pakuyesa kwachipatala kwa pachimake matenda pancreatitis, ndipo mu zoyeserera za vitro zimagwiritsidwa ntchito kwa ma cell. Kuphatikiza apo, imagwiritsidwa ntchito poyeserera mayeso a ndulu.

Mwachidule ndi kugwiritsa ntchito certuren

Zambiri mwatsatanetsatane

Mawonekedwe: oyera oyera

Nambala ya Cas: 1760-98-5

Gutuo No.: GT-F055

Mndandanda: pglu-gln-asn-asr (sokha) -thy-gly-trp-asp-phe-zh2

Mawonekedwe a mamolecular: c58h73n13o21s

Kulemera kwa maselo: 1352.4

Kusungunuka: kusungunuka mu 50mm ammonium hydroxide pa kukhazikika kwa 1.0mg / ml

Karata yanchito

1. Amagwiritsidwa ntchito kwambiri mu mtundu wa pachimake wovuta pancreatitis pamayesero azachipatala.

2. Kugwiritsa ntchito kwa ma cell mu vitro.

3. Kugwiritsidwa ntchito poyesa kwa gallbladder.

Kuti mukhale ndi chitsanzo pophunzira pancreatitis pachimake pophunzira certure (ma ap) pafoni, mawonekedwe a pathophysyogical ndi mawonetseredwe a matenda oopsa pancreatitis. Kuphatikiza pa kufufuzanso zosintha za m'mapapo, zitha kuwonetsanso kuyanjana kwa ma vistecral endocrine monga metabolin ndi cck. Itha kugwiritsidwanso ntchito kuwunika kukonzanso ndikubwezeretsa zopweteka zovulaza pambuyo pakuchotsa zinthu zowopsa.

5. Kugwiritsa ntchito caulelein certulen (cerulein) ndi LPS kuti akhazikitse mitundu ya kapamwamba ikhoza kupanga ma encreatitic mitundu, yomwe kale ingalimbikitse michere yowononga yowononga kapamba. Pambuyo pake, LPS imasokoneza kuyankha kwabwinobwino kwa opatsa thupi, motero akupanga kapaka komwe amakhala ngati otupa kwambiri otupa.

6. Certulein angagwiritsidwe ntchito popewa kupweteka kwa ndulu, aimpso colic, ndi kupweteka kwa centmittent. Amaganiziridwa kuti ndi a Kephalin Ogogomest.