Palmitoyl pentapeptide-4 imatha kusintha khungu la nkhope

Palmitoyl pentapeptide-4 nthawi zambiri imagwiritsidwa ntchito ngati gel osakaniza polimbana ndi makwinya.

Palmitoyl pentapeptide-4 (pre-2006 palmitoyl pentapeptide-3) imagwiritsidwa ntchito kwambiri ngati gel osakaniza polimbana ndi makwinya otsimikizira zosamalira khungu.Ndi ku Spain skin care yogwira pophika mu 2000 monga makampani awo chisamaliro monga chosakaniza yogwira, palmitoyl pentapeptide-4 ndiye peptide mndandanda wa ntchito koyambirira ndi polypeptide ambiri ankagwiritsa ntchito, zoweta ndi akunja zopangidwa otchuka kwambiri ntchito monga Chinsinsi chothandiza pakusamalira khungu loletsa makwinya, muzinthu zambiri zosamalira khungu zolimbana ndi makwinya nthawi zambiri zimawonekera pachithunzi chake.Powonjezera collagen kupyolera mu dermis, imatha kusintha ukalamba mwa kumanganso khungu kuchokera mkati.Kumakhudza kolajeni, zotanuka ulusi ndi hyaluronic acid kuwonjezeka, kuwonjezera chinyezi pakhungu ndi kusunga chinyezi, kuwonjezera makulidwe khungu ndi kuchepetsa mizere yabwino.

Palmitoyl pentapeptide-4 (Pal-lys-thr-Lys-ser = Pal-KTTKS) ili ndi ma amino acid asanu olumikizidwa ndi unyolo wa 16-carbon aliphatic kuti apititse patsogolo kutulutsa kwa molekyulu kudzera mu kapangidwe ka lipid pakhungu.Ichi ndi margarine.Palmitoyl pentapeptide-4 ndi messenger peptide yomwe imayang'anira magwiridwe antchito a cell polumikizana ndi ma receptor awo enieni.Iwo adayambitsa majini omwe amakhudzidwa ndi kukweza kwa matrix a extracellular ndi kuchuluka kwa ma cell.Palmitoyl pentapeptide-4 imakhala ndi anti-khwinya komanso kulimbitsa khungu poyambitsa kaphatikizidwe katsopano ka ma macromolecules mu matrix a extracellular.

Njira yochitira

Kafukufuku wa in vitro adapeza kuwonjezeka kwa 212% kwa mtundu wa I collagen kaphatikizidwe, kuwonjezeka kwa 100% mpaka 327% mu kaphatikizidwe ka collagen IV, ndi 267% kuwonjezeka kwa hyaluronic acid synthesis.Collagen I imapezeka mumitundu yambiri ya 19 ya collagen m'thupi.Chifukwa chake, kuchulukitsa kuchuluka kwa collagen I kumakhudza kwambiri kukonzanso khungu.Kufufuza kwa miyezi isanu ndi umodzi mu vivo kunapeza kuchepa kwapakati pa 17 peresenti mu kuya kwa mizere yabwino, 68 peresenti pamtunda wa mizere yozama kwambiri, 51 peresenti pamtunda wa mizere yabwino kwambiri, ndi 16 peresenti m'makwinya a khungu.