PYY peptides ndi antifungal ndipo amasunga thanzi lamatumbo am'mimba

Gululo litazindikira mtundu uwu wa ma C. albicans omwe amagwiritsa ntchito PYY, zomwe zidawonetsa kuti PYY idaletsa bwino kukula kwa mabakiteriyawa, kupha mitundu yambiri ya mafangasi a C. albicans ndikusunga yisiti yamtundu wa C. albicans.

Gulu la Eugene Chang ku yunivesite ya Chicago lasindikiza pepala mu magazini ya Science yakuti: Peptide YY: A Paneth cell antimicrobial peptide yomwe imasunga Candida gut commensalism.

YY peptide (PYY) Ndi mahomoni am'mimba omwe amawonetsedwa ndikutulutsidwa ndi ma cell a enteroendocrine (ECC) kuti azitha kuletsa kudya potulutsa kukhuta.Kafukufuku waposachedwapa apeza kuti matumbo a PanethCell omwe siachindunji akuwonetsanso mawonekedwe a PYY, omwe amatha kukhala ngati antimicrobial peptide (AMP), yomwe imathandizanso kwambiri kuti matumbo aang'ono azikhala athanzi komanso kuteteza ma Candida albicans kuti asakhale owopsa. mode.

Zochepa zimadziwika pakuwongolera kwa mabakiteriyawa ndi gut microbiome yathu.Timangodziwa kuti mabakiteriya ali kunja, koma sitikudziwa chomwe chimawapangitsa kukhala abwino pa thanzi lathu.Kafukufuku waposachedwa wawonetsa kuti ma YY peptides ndiofunikira kwenikweni pakusunga matumbo a bakiteriya symbiosis.

Poyambirira, gululo silinali lokonzeka kuphunzira mabakiteriya m'matumbo a microbiome.Pamene Joseph Pierre, mlembi woyamba wa pepalali, anali kuphunzira m'mimba maselo a endocrine a PYY opanga mbewa, Dr. Joseph Pierre anaona kuti PYY ilinso ndi Panethcells, omwe ndi ofunikira chitetezo cham'thupi m'matumbo a mammalian ndikuletsa kuchulukitsa kwa mabakiteriya owopsa. pogwiritsira ntchito mankhwala angapo a bacterosuppressive.Izi sizikuwoneka zomveka chifukwa PYY poyamba ankaganiziridwa kuti ndi hormone ya chilakolako chofuna kudya.Gululo litazindikira mabakiteriya osiyanasiyana, PYY idapezeka kuti ndiyoyipa pakuwapha.

PYY peptides ndi antifungal ndipo amasunga thanzi lamatumbo am'mimba

Komabe, atafufuza mitundu ina ya peptide yofananira, adapeza peptide ngati PYY -Magainin2, antimicrobial peptide yomwe ilipo pakhungu la Xenopus lomwe limateteza ku matenda a bakiteriya ndi mafangasi.Chifukwa chake, gululi lidayamba kuyesa mphamvu za antifungal za PYY.M'malo mwake, PYY sikuti ndi antifungal wothandizira kwambiri komanso ndi antifungal wothandizira kwambiri.

PYY yosasunthika, yosasinthika ili ndi ma amino acid 36 (PYY1-36) ndipo ndi peptide yamphamvu ya antifungal pamene ma cell a Paneth amalowa m'matumbo.Koma maselo a endocrine akatulutsa PYY, amachotsedwa ma amino acid awiri (PYY3-36) ndikusandulika kukhala hormone ya m'mimba yomwe imatha kuyenda m'magazi kuti ipange chidziwitso chokwanira chomwe chimauza ubongo kuti ulibe njala.

Candida albicans (C.albicans), yemwe amadziwikanso kuti Candida albicans, ndi tizilombo tomwe timamera mkamwa, khungu ndi matumbo.Ndi commensal m'thupi mu mawonekedwe a yisiti, koma pansi pamikhalidwe yocheperako imatembenuka kukhala mawonekedwe otchedwa mafangasi, omwe amalola kuti ikule mochuluka, zomwe zimatsogolera ku thrups, matenda am'kamwa ndi mmero, matenda a nyini, kapena zovuta kwambiri. matenda opatsirana.

Gululo litazindikira mtundu uwu wa ma C. albicans omwe amagwiritsa ntchito PYY, zomwe zidawonetsa kuti PYY idaletsa bwino kukula kwa mabakiteriyawa, kupha mitundu yambiri ya mafangasi a C. albicans ndikusunga yisiti yamtundu wa C. albicans.