Pali mitundu yambiri ya transmembrane peptides, ndipo gulu lawo limakhazikika pathupi ndi mankhwala, mapangidwe, mankhwalawa, kuphatikiza mapangidwe ake, komanso ntchito zamagetsi. Malinga ndi matenda awo akuthupi ndi mankhwala, nembanene zolowera m'matumbo zitha kugawidwa m'mitundu itatu: castic, ompipicilic ndi hydrophobic. CATIC ndi AMPILICIC Membrane Kulowera ku Peptides kwa 85%, pomwe hydrophobic membrane kulowetsa akaunti ya mapepu 15% okha.
1. METICE MEmbrane wolowa mu peptide
Cistic Transmerane Peptides zimapangidwa ndi zigawo zazifupi kwambiri, lysine, ndi histidine, monga tattidine, penetidin, polneti, ndi DPV3 ndi DPV3 ndi D22n. Pakati pawo, Arginine ali ndi guwadine, omwe amatha kukhala ndi hydrogen movutikira mabungwe a acid pa cell nembanemba ndi matembenuzidwe amtundu wa mu nembanemba. Maphunziro a oligarginine (kuyambira 3 R mpaka 12 R) kuwonetsa kuti luso la membrane lidatheka pokhapokha ngati kuchuluka kwa a Arginine pang'onopang'ono. Nyimbo ya lysine, ngakhale ili ndi tsankho monga gunididine, pomwe ali okha, a vembrane invuner iloteration yake siyokwera kwambiri. Futchaki et al. . Ngakhale kuti acita omwe ali ndi ma amno atsalira okhazikika kuti alowe m'matumbo omwe amalowa nawo kuti alowe mu nembanemba, ena amino acid ndizofunikira, monga momwe w14 amasinthira mu F, kulowa wa Pertratin atayika.
Gulu lapadera la commentmbrane lappides ndi mndandanda wazotsatira zanyukiliya (nlss), zomwe zimakhala ndi zigawo zazifupi kwambiri, lysine ndi proline ndipo imatha kutumizidwa ku nyukiliya kudutsa mu nyukiliya. NLSS ikhoza kugawidwa muinatiyi ndi kuyimira kawiri, yopangidwa ndi magulu amodzi ndi awiri a ma amino acid. Mwachitsanzo, pkkkrkv kuchokera ku ma virus a Sin Havers 40 (SV40) ndi imodzi yolemba nls, pomwe mapuloteni a nyukiliya amatulutsa kawiri. Krpaatkkagqkkkl ndiye gawo lalifupi lomwe lingakhale ndi gawo la membrane tramprane. Chifukwa chakuti llss amalipiritsa manambala ochepera 8, NLSS sinagwire ma traprambrane, koma akhoza kukhala othandiza traverane mapepu a hydrophobic popsilic plupsilic Transmerane Peptider.
2. APPHilic Transmerane peptide
Ampufilic Transmerane Peptives amakhala ndi hydrophilic ndi hydrophobic domas, omwe amatha kugawidwa koyamba, kachiwiri kakang'ono kamene kamfirifilic, opindika opindika.
Mtundu woyamba APAGIhilic amavala ma meprane m'magulu awiri, gulu lolumikizidwa ndi phompho ya SV40, pomwe hydrophobic ya MPG ikukhudzana ndi matenda a Hiv Glycoteagsg A), ndipo madera a Hydrophabic Olemera A) Komabe, madera a Hydrophobic a zonsezi amalumikizidwa ndi zikwangwani zanyukiliya za Pkkkrkv kudzera pa WSQP. Kalasi ina ya omwe amamugwirizira Transmembrane Peptives adatalikirana ndi mapuloteni achilengedwe, monga pvec, Arf (1-22) ndi BPPRPR (1-28).
Sekondale í-Hustical Comphililic Transmerane Peprambrane imangirira nex-herdophilic amino otsalira amalinolimo a acid pamalo a hekalamo). Kwa mtundu wa Beta Plapting Commudisic mtundu wa TopAfihilic, kuthekera kwake kupanga pepala la better Cholinganizidwa, luso la nembane la member ndi losauka kwambiri. Pakunjezani ku Prolilic Transmembrane Peptides, polyupineine II (PPII) amapangidwa mosavuta m'madzi oyera pomwe ma proline amalemeretsa kwambiri mu polytetide. PPII ndi helix yosiyidwa ndi 3.0 amino atsalira okhazikika pa nthawi yotembenukira, osati kutsutsana ndi mawonekedwe oyenera a alpha-alfix omwe ali ndi 3.6 amino anid otsalira. Kuchulukitsa ku Prolifilic Transmerane Peptides kunaphatikizapo Bovicrobial Peptide 7 (PRP7), n (n utha kukhala 3, 4, 5), etc.
3. Hydrophobic Membrane Kulowa Traptide
Hydrophobic Transmerane Peptides ali ndi polar amno acid, ndi net rin of the acid, kapena kukhala ndi ma hydrophobic ozungulira kapena magulu a mankhwala omwe ndi ofunikira pakusintha. Ngakhale ma cell ma cellularmbrane omwe nthawi zambiri amanyalanyazidwa, amakhalapo, monga fabroglast factor (k-fgf) ndi fakitala wa fibroglast 12 (F-GF12) kuchokera ku Saposi ya Kaposi.
Post Nthawi: 2025-07-01