Glucagon-like peptide 1 receptor (GLP-1R) agonists apezeka kuti amachepetsa kumwa mowa mwa makoswe komanso anthu onenepa kwambiri omwe ali ndi vuto lakumwa mowa (AUD).Komabe, mlingo wochepa wa semaglutide (semaglutide), inhibitor wamphamvu wa GLP-1, wasonyezedwa kuti umachepetsa kumwa mowa mwa makoswe ndi anthu onenepa kwambiri omwe ali ndi AUD.Kuthekera kwakuti agonist yemwe ali ndi mphamvu zambiri komanso kuyanjana kwa GLP-1R) amatsitsa mayankho okhudzana ndi mowa mu makoswe, komanso njira zomwe zili m'munsi mwa minyewa, sizikudziwika.
Somallutide, mankhwala omwe panopo amagwiritsidwa ntchito pochiza matenda a shuga amtundu wa 2 komanso kunenepa kwambiri, atha kukhala chithandizo chothandizira kudalira mowa.mu kafukufuku wofalitsidwa mu nyuzipepala yapadziko lonse ya eBioMedicine yotchedwa "Semaglutide Imachepetsa Kumwa Mowa ndi Kumwa Mowa M'makoswe Aamuna ndi Aakazi," Asayansi ochokera ku yunivesite ya Gothenburg ndi mabungwe ena apeza kuti somallutide ikhoza kuchepetsa kumwa mowa mwauchidakwa komanso kumwa mowa mwa makoswe. kuposa theka.
Kufuna kwa somallutide, kugulitsidwa pansi pa mayina amtundu monga Ozempic (semaglutide), kwawonjezeka kuyambira pamene mankhwalawa adavomerezedwa kuti athetse kunenepa kwambiri, zomwe posachedwapa zakhala zovuta kwambiri kuzipeza;Pakhalanso malipoti osaneneka onena za anthu onenepa kwambiri kapena matenda a shuga akuti chilakolako chawo cha mowa chidachepa atayamba kumwa mankhwalawa.Masiku ano, anthu omwe ali ndi vuto lakumwa mowa mwauchidakwa amathandizidwa ndi njira zosiyanasiyana zamaganizidwe komanso mankhwala osokoneza bongo.Panopa pali mankhwala anayi ovomerezeka.Popeza kuti kumwa mowa mwauchidakwa ndi matenda omwe ali ndi zifukwa zambiri komanso mphamvu zosiyanasiyana za mankhwalawa, kupanga njira zochiritsira ndizofunikira kwambiri.
Somallutide ndi mankhwala omwe amagwira ntchito nthawi yayitali omwe odwala amangofunika kumwa kamodzi pa sabata, ndipo ndi mankhwala oyamba kuchitapo kanthu pa GLP-1 receptor omwe amatha kutengedwa ngati piritsi.Mu kafukufukuyu, ochita kafukufuku adachiritsa makoswe omwe amamwa mowa ndi somalitide, zomwe zimachepetsa kwambiri makoswe omwe amamwa mowa komanso kuchepetsa kumwa komwe kumakhudzana ndi kuyambiranso, vuto lalikulu kwa anthu omwe amamwa mowa chifukwa anthu amayambiranso pambuyo pa nthawi yodziletsa komanso kumwa mowa wambiri. kuposa momwe adachitira kale asanadzile.Makoswe ochiritsidwawo adatha kuchepetsa kumwa mowa ndi theka poyerekeza ndi makoswe osagwiritsidwa ntchito, ofufuzawo adanena.Chochititsa chidwi mu phunziroli chinali chakuti somallutide inachepetsa kumwa mowa mofanana ndi makoswe amuna ndi akazi.
Phunziroli linanenanso zotsatira zabwino zodabwitsa, ngakhale kuti maphunziro a zachipatala a somallutide akadali kutali kwambiri asanagwiritsidwe ntchito pochiza kumwa mowa;Kupita patsogolo, mankhwalawa akhoza kukhala opindulitsa kwambiri kwa anthu omwe ali ndi kunenepa kwambiri komanso kudalira mowa, ndipo ochita kafukufuku amanena kuti zotsatira zake zikhoza kupita kwa anthu, monga momwe maphunziro ena a mankhwala osokoneza bongo omwe amagwiritsa ntchito mankhwala okhudzana ndi kafukufuku amasonyeza kuti anthu akhoza kukhala ndi zotsatira zochiritsira zofanana kapena zotsatira zake. ngati makoswe.Pulofesa Elisabet Jerlhag akunena kuti, ndithudi, pali kusiyana pakati pa kafukufuku wochitidwa pa zinyama ndi anthu, ndipo ochita kafukufuku ayenera nthawi zonse kuganizira kusiyana kumeneku;Pankhaniyi, komabe, kafukufuku wam'mbuyomu mwa anthu adawonetsa kuti mtundu wakale wamankhwala a shuga omwe amagwira ntchito pa GLP-1 adapezeka kuti amachepetsa kumwa mowa mwa anthu onenepa kwambiri omwe amamwa mowa.
Kafukufuku wamakono adafufuzanso chifukwa chake mankhwala a somallutide amachepetsa kumwa mowa mwauchidakwa, kutanthauza kuti kuchepetsa mphotho za ubongo zomwe zimayambitsidwa ndi mowa ndi zilango zingakhale zomwe zikuthandizira;Mu pepalalo, ofufuzawo adapeza kuti zimakhudza dongosolo la mphotho ndi chilango cha ubongo wa mbewa.Makamaka, zimakhudza dera la nucleus accumbens, lomwe ndi gawo la limbic system.Ofufuzawo amakhulupirira kuti mowa umayambitsa mphotho ya ubongo ndi dongosolo la chilango, zomwe zimapangitsa kuti dopamine atuluke, yomwe imatha kuwonedwa mwa anthu ndi nyama, ndipo njirayi imatsekedwa pambuyo pochiritsidwa mbewa, zomwe zingapangitse kuti pakhale mphotho yochepa yoledzera mowa. chilango m'thupi, ofufuza amakhulupirira.
Pomaliza, zotsatira za kafukufukuyu zikuwonetsa kuti somallutide imatha kuchepetsa kumwa mowa, zomwe zitha kulumikizidwa ndi kuchepetsedwa kwa mphotho / chilango chomwe chimapangidwa ndi mowa komanso momwe ma nucleus accumbens amagwirira ntchito."Monga somallutide idachepetsanso kulemera kwa thupi mwa amuna ndi akazi onse a makoswe omwe amamwa mowa, maphunziro azachipatala amtsogolo adzawona momwe somallutide imathandizira kuchepetsa kumwa mowa komanso kulemera kwa thupi kwa odwala onenepa kwambiri omwe ali ndi vuto lakumwa mowa."
Nthawi yotumiza: Nov-07-2023