Pepalali likufotokoza mwachidule ticcotide ndi zotsatira zake pazamankhwala

Tecosactidendi analogue ya 24-peptide corticotropin.Mndandanda wa amino acid ndi wofanana ndi 24 amino acid wa amino-terminal ya corticotropin yachilengedwe (anthu, ng'ombe ndi nkhumba), ndipo imakhala ndi zochitika zofanana ndi thupi lachilengedwe la ACTH."Zimadziwika ndi kusakhalapo kwa ma antibody, nthawi zambiri popanda zotsatira zoyipa, ndipo ndizofunikira makamaka kwa odwala omwe sakhudzidwa kapena osagwira ntchito ndi corticotropin yachilengedwe."

"Zimayambitsa adrenal hyperplasia, zimathandizira kutulutsidwa kwa mahomoni a adrenocortical, makamaka (cortisol) ndi mineralocorticoids ena monga corticosterone, komanso amathandizira katulutsidwe ka androgens, koma ndi mphamvu yofooka."

Pepalali likufotokoza mwachidule ticcotide ndi zotsatira zake pazamankhwala

Panalibe zotsatira zochepa pakutulutsa kwa aldosterone.Theka la moyo ndi 3 hours.Mu 2008, a FDA adavomereza Tecokotide kuchokera ku Novartis kuti adziwe matenda a adrenal insufficiency.Pakali pano ikuphunziridwa ku RandboudUniversity pochiza idiopathic membranous nephropathy.

Njira yonse yamadzimadzi gawo kaphatikizidwe ndi kaphatikizidwe njira ya ticacotide.Njirayi ili ndi masitepe ambiri, nthawi yayitali ya kaphatikizidwe, ndipo imafuna zopangira zokwera mtengo komanso zida zothamanga kwambiri, zomwe zimakhala ndi zovuta zotsika mtengo, zonyansa zambiri, ngozi yantchito, komanso zokolola zochepa.Zanenedwa kuti kaphatikizidwe mmodzi ndi mmodzi pogwiritsa ntchito njira ya Z-chitetezo, momwe hydrogenation imagwiritsidwa ntchito kuchotsa maziko otetezera pa sitepe iliyonse, imakhala ndi masitepe aatali, ntchito yovuta, yotsika mtengo komanso yotsika mtengo.Serine imakonda kuthamangitsidwa chifukwa cha kulumikizana kwa wina ndi mnzake pakuyeretsedwa, komwe kumakhala kovuta kuyeretsa.

"Monga timadzi ta adrenocorticotropic, ticcotide imathandizira kutulutsidwa kwa mahomoni a cortical (makamaka cortisol) kuchokera ku adrenal cortex."Choncho, panalibe zotsatira odwala kwambiri adrenocortical kukanika.

Ticocotide ndi polypeptide yopanga yokhala ndi 24 amino acid.Ndilofanana m'mapangidwe ake oyambirira mpaka 24 amino acid a ACTH.Kulowetsedwa m'mitsempha kumawonjezera kuchuluka kwa cortisol m'magazi.Kudontha kosalekeza kwa mtsempha kuyenera kugwiritsidwa ntchito kusunga kuchuluka kwa cortisol m'magazi.Pa jakisoni wa mu mnofu, seramu cortisol idafika pachimake pa ola limodzi mutatha jekeseni.Pambuyo pake, cortisol yokwezeka imatha kusungidwa pafupifupi maola 24.