mawu oyamba
Gorelatide, yomwe imadziwikanso kuti n-acetyl-serine - aspartic acid - proline - proline -(N-Acetyl-Ser-Asp-Ls-Pro), yofupikitsidwa kuti Ac-SDKP, ndi tetrapeptide yokhazikika, nitrogen end acetylation, imafalitsidwa kwambiri zosiyanasiyana zimakhala ndi madzimadzi a m'thupi m'thupi.Tetrapeptide iyi imatulutsidwa ndi prolyl oligopeptidase (POP), yomwe imayambitsidwa makamaka ndi kalambulabwalo wake wa thymosin.Kuchuluka kwa magazi m'magazi nthawi zambiri kumakhala pamlingo wa nanomole.
okinetics
Malinga ndi kafukufuku wa pharmacokinetic wa Gorelatide, pambuyo pa jekeseni wamtsempha, Gorelatide imatsitsa mwachangu ndi theka la moyo wa 4 ~ 5min.Gorelatide imachotsedwa ku plasma yamunthu ndi njira ziwiri:①Angiotensin-akatembenuka enzyme (ACE) - kutsogoleredwa ndi hydrolysis;②Kusefera kwa Glomerular.Hydrolysis ya angiotensin converting enzyme (ACE) ndiye njira yayikulu ya metabolism ya gorelatide.
Zochita zamoyo
Gorelatide ndi mtundu wa multifunctional physiological regulatory factor yokhala ndi zochitika zosiyanasiyana zachilengedwe.Zinanenedwa kale kuti Gorelatide ikhoza kulepheretsa kulowa kwa maselo oyambirira a hematopoietic mu gawo la S ndikuwapangitsa kukhala okhazikika mu gawo la G0, kulepheretsa ntchito ya maselo amtundu wa hematopoietic.Pambuyo pake zidadziwika kuti Gorelatide imatha kupititsa patsogolo mphamvu yobzalanso epidermal mwa kulimbikitsa mapangidwe a mitsempha yamagazi ndikufulumizitsa machiritso a zilonda m'mitsempha yowonongeka ya epidermal.Gorelatide imatha kuletsa kusiyanitsa kwa maselo amtundu wa mafupa omwe amalimbikitsidwa ndi MGM kukhala macrophages, motero amasewera gawo loletsa kutupa.Gorelatide yapezeka posachedwa kuti imalepheretsa kuchuluka kwa maselo osiyanasiyana.
ntchito
Monga polypeptide organic matter, Gorelatide itha kugwiritsidwa ntchito ngati mankhwala opangira mankhwala.
Nthawi yotumiza: Apr-26-2023