Kodi ma peptides olowera ma cell ndi ati?

Peptides yolowera maselo ndi ma peptides ang'onoang'ono omwe amatha kulowa mu cell membrane. Kalasi iyi ya mamolekyulu, makamaka ma CPP omwe ali ndi ntchito zoyambira, amakhala ndi lonjezo loti mupeze mankhwala othandiza kwa mankhwala osokoneza bongo.

Chifukwa chake, kafukufukuyu ali ndi tanthauzo linalake. Mu kafukufukuyu, ma cpps omwe ali ndi zochitika zosiyanasiyana transmerane adaphunziridwa pamlingo wotsatira, kuyesera kuti adziwe zomwe zikukhudzana ndi ma CPPs omwe ali ndi zochitika zosiyanasiyana komanso zosakanikirana ndi kusanthula kwachilengedwe.

Ma CPPS ndi ma pppps ma CPSPs adapezeka kuchokera ku database ya CPPIT ndi chidziwitso chosiyanasiyana, ndi ma typps, mabpps, ndi trapps, ndi trawnmerane yotsika yomwe imachotsedwa pamagawo a CPP. Kutengera ndi zomwe zakhazikitsidwa, maphunziro otsatirawa adachitika:

1, Amino acid ndi sekondale kapangidwe ka cpps yosiyanasiyana ya ma cpps komanso osakanizidwa ndi Aniva. Zinapezeka kuti ma elekitirotic komanso hydrophobic mogwirizana ndi ma amino acid omwe amathandizira gawo lofunikira mu transmerane ntchito yofunika kwambiri ya CPPS, ndipo mawonekedwe a hercucal komanso kubveka mwachisawawa adakhudzanso transmerane ntchito yogwira ntchito.

2. Mphamvu zathupi ndi zamankhwala ndi kutalika kwa ma cpps okhala ndi zochitika zosiyanasiyana zidawonetsedwa pa ndege ziwiri. Zinapezeka kuti ma CPPs ndi zosagwirizana ndi zochitika zosiyanasiyana zitha kuphatikizidwa ndi katundu wapadera, ndipo HCPPS, macps, lcpps ndi osagawika m'masango atatu, kuwonetsa kusiyana kwawo;

3. Mu pepala ili, lingaliro la centroid yolimbitsa thupi ndi mankhwala ogwiritsira ntchito, ndipo zotsalira zomwe zimapanga mndandandawu zimawonedwa ngati mfundo za tinthu, ndipo mndandandawo umazimiririka ngati chinthu cha tinthu ta kafukufuku. Njirayi idagwiritsidwa ntchito powunikira ma CPP

Kafukufukuyu ali ndi tanthauzo la kapangidwe ka ma CPPs ndikumvetsetsa kusiyana kwa ma CPPs ndi zochitika zosiyanasiyana. Kuphatikiza apo, njira yoperekera mindandanda yamitundu yoyendetsera zinthu zachilengedwe yomwe idayambitsidwa mu pepala ili imatha kugwiritsidwanso ntchito powunikira mavuto ena achilengedwe. Nthawi yomweyo, atha kugwiritsidwa ntchito ngati magawo a magawo ena a kagulu kazinthu zachilengedwe ndipo amatenga mbali povomerezeka.