Kodi phosphorylation mu peptides ndi chiyani?

Phosphorylation imakhudza mbali zonse za moyo wa ma cell, ndipo mapuloteni kinases amakhudza mbali zonse za ntchito zoyankhulirana zamkati mwa kulamulira njira zowonetsera ndi ma cellular.Komabe, aberrant phosphorylation ndi chifukwa cha matenda ambiri;makamaka, mutated protein kinases ndi phosphatase zingayambitse matenda ambiri, ndipo poizoni ambiri achilengedwe ndi tizilombo toyambitsa matenda amakhalanso ndi zotsatira mwa kusintha phosphorylation ya mapuloteni okhudza maselo ambiri.

Phosphorylation ya serine (Ser), threonine (Thr), ndi tyrosine (Tyr) ndi njira yosinthira mapuloteni.Amatenga nawo gawo pakuwongolera zochitika zambiri zama cell, monga ma receptor signing, protein association ndi segmentation, kuyambitsa kapena kuletsa ntchito ya mapuloteni, komanso kupulumuka kwa maselo.Phosphates imayimbidwa moyipa (malipiro awiri olakwika pagulu la phosphate).Choncho, kuwonjezera kwawo kumasintha zinthu za puloteni, zomwe nthawi zambiri zimakhala zosinthika, zomwe zimapangitsa kuti pakhale kusintha kwa mapuloteni.Gulu la phosphate likachotsedwa, kupangidwa kwa puloteni kumabwerera ku chikhalidwe chake choyambirira.Ngati mapuloteni awiriwa akuwonetsa zochitika zosiyanasiyana, phosphorylation imatha kukhala ngati chosinthira mamolekyulu kuti mapuloteniwo aziwongolera zomwe amachita.

Mahomoni ambiri amayendetsa ntchito ya ma enzymes enieni powonjezera phosphorylation state ya serine (Ser) kapena threonine (Thr) zotsalira, ndipo tyrosine (Tyr) phosphorylation ikhoza kuyambitsidwa ndi kukula kwa zinthu (monga insulini).Magulu a phosphate a ma amino acid amenewa akhoza kuchotsedwa mwamsanga.Chifukwa chake, Ser, Thr, ndi Tyr amagwira ntchito ngati masinthidwe a maselo pakuwongolera zochitika zama cell monga kuchuluka kwa chotupa.

Ma peptides opangidwa amakhala ndi gawo lothandiza kwambiri pofufuza magawo a protein kinase ndi kuyanjana.Komabe, pali zinthu zina zomwe zimalepheretsa kapena kuchepetsa kusinthika kwaukadaulo wa kaphatikizidwe wa phosphopeptide, monga kulephera kukwaniritsa zodziwikiratu za kaphatikizidwe kolimba komanso kusalumikizana bwino ndi nsanja zowunikira.

Pulatifomu yokhazikitsidwa ndi peptide synthesis ndi phosphorylation modification technology imagonjetsa zofookazi ndikuwongolera kaphatikizidwe kabwino kaphatikizidwe ndi scalability, ndipo nsanjayo ndiyoyenera kuphunzira za magawo a protein kinase, ma antigen, mamolekyu omangira, ndi zoletsa.