Masiku ano, kunenepa kwakhala mliri wapadziko lonse lapansi, ndipo kuchuluka kwa kunenepa kwambiri kwakwera kwambiri m'maiko padziko lonse lapansi.Malinga ndi zimene bungwe la World Health Organization linanena, akuti anthu 13 pa 100 alionse achikulire padziko lonse ndi onenepa kwambiri.Chofunika koposa, kunenepa kwambiri kumatha kuyambitsa metabolic syndrome, yomwe imatsagana ndi zovuta zosiyanasiyana monga mtundu wa 2 shuga mellitus, kuthamanga kwa magazi, nonalcoholic steatohepatitis (NASH), matenda amtima, ndi khansa.
Mu June 2021, a FDA adavomereza Semaglutide, mankhwala ochepetsa thupi opangidwa ndi Novo Nordisk, monga Wegovy.Chifukwa cha zotsatira zake zabwino zowonda, mbiri yabwino yachitetezo komanso kukankhira kwa anthu otchuka ngati Musk, Semaglutide yakhala yotchuka kwambiri padziko lonse lapansi kotero kuti ndizovuta kupeza.Malinga ndi lipoti lazachuma la Novo Nordisk la 2022, Semaglutide idagulitsa mpaka $ 12 biliyoni mu 2022.
Posachedwapa, kafukufuku wofalitsidwa mu Journal anasonyeza kuti Semaglutide imakhalanso ndi phindu losayembekezereka: kubwezeretsa ntchito ya maselo akupha (NK) m'thupi, kuphatikizapo kupha maselo a khansa, omwe samadalira kulemera kwa mankhwala ochepetsa thupi.Phunziroli ndi nkhani yabwino kwambiri kwa odwala onenepa kwambiri omwe amagwiritsa ntchito Semaglutide, kutanthauza kuti mankhwalawa ali ndi phindu lalikulu la kuchepetsa chiopsezo cha khansa kuphatikizapo kulemera.Mbadwo watsopano wa mankhwala, woimiridwa ndi Semaglutide, ukusintha chithandizo cha kunenepa kwambiri ndipo wadabwitsa ofufuza ndi zotsatira zake zamphamvu.
Ndiye, ndani angachepetse thupi kuchokera pamenepo?
Kwa nthawi yoyamba, gululi linagawa anthu onenepa m'magulu anayi: omwe amafunikira kudya kwambiri kuti akhute (njala yaubongo), omwe amadya monenepa koma amamva njala pambuyo pake (njala ya m'matumbo), omwe amadya kuti apirire. malingaliro (njala yamalingaliro), ndi omwe ali ndi kagayidwe kake pang'onopang'ono (matabolism otsika).Gululo lidapeza kuti odwala onenepa kwambiri omwe amadwala m'matumbo amayankha bwino kwambiri kumankhwala atsopanowa ochepetsa thupi pazifukwa zosadziwika, koma ofufuzawo adaganiza kuti mwina ndichifukwa chakuti milingo ya GLP-1 sinali yokwera, ndichifukwa chake adalemera ndipo, chifukwa chake, amalemera bwino. kutayika ndi GLP-1 receptor agonists.
Kunenepa kwambiri tsopano kumaonedwa kuti ndi matenda aakulu, choncho mankhwalawa akulimbikitsidwa kuti athandizidwe kwa nthawi yaitali.Koma ndi nthawi yayitali bwanji?Sizikudziwika bwino, ndipo iyi ndi njira yomwe iyenera kufufuzidwa.
Kuwonjezera apo, mankhwala atsopanowa ochepetsa thupi anali othandiza kwambiri moti ofufuza ena anayamba kukambirana za kuchuluka kwa kulemera komwe kunatayika.Kuonda sikungochepetsa mafuta komanso kumayambitsa kutayika kwa minofu, ndipo kuwonongeka kwa minofu kumawonjezera chiopsezo cha matenda a mtima, osteoporosis, ndi zina, zomwe zimadetsa nkhawa kwambiri okalamba ndi omwe ali ndi matenda a mtima.Anthuwa amakhudzidwa ndi zomwe zimatchedwa kunenepa kwambiri - kuti kuchepa kwa thupi kumagwirizanitsidwa ndi imfa zambiri.
Choncho, magulu angapo ayamba kufufuza zotsatira za mlingo wochepa wa kugwiritsa ntchito mankhwala atsopanowa kuti athe kuthana ndi mavuto okhudzana ndi kunenepa kwambiri, monga kubanika, matenda a chiwindi chamafuta, ndi matenda a shuga a mtundu wa 2, zomwe sizimafunika kuchepetsa thupi.
Nthawi yotumiza: Oct-23-2023