ZP7570 (Dapiglutide) Ogulitsa / 2296814-85-0 /0 / Trepdide

Kaonekeswe

Dapiliglutide (ZP7570) ndi glucagon yayitali - ngati peptide 1r (glucagon) / glucagon-ngati peptide 2 reptist (Glp-2R). Dapiglutide ikhoza kugwiritsidwa ntchito munthawi yachidule (SBS) kafukufuku kuti muchepetse matumbo osakhazikika mu chithunzi cha bowa wachidule, ndi zotsutsana ndi kunenepa.

Kulembana

Kubwera: zoyera kuti ukhale wopanda ufa

Kuyera (HPLC): ≥98.0%

Kudetsa Kwake: ≤2.0%

Zambiri za Acetate (HPLC): 5.0%～12.0%

Madzi (Karl Fischer): ≤10.0%

Zolemba patsamba: ≥80.0%

Kulongedza ndi kutumiza: kutentha kochepa, kutentha kwa vacuum, molondola kwa mg monga amafunikira.

FAQ：

Ndi njira iti yabwino kwambiri yofufuzira?

Mwachisawawa, peptide imatha ndi gulu la N-termial Free Amino ndi Gulu la C-Termial Free Carboxyl. Pulogalamu ya Peptide nthawi zambiri imayimira mndandanda wa protein. Kuti tikhale pafupi ndi mapuloteni amayiwo, kumapeto kwa peputiyi nthawi zambiri kumafunikira kutsekedwa, ndiye kuti, ma termial acetylay ndi ma tekidal. Kusintha kumeneku kumapewa kuyambitsa kwa chiwopsezo chowonjezera, komanso kumapangitsa kuti alepheretse kuchitapo kanthu mopupuluma, kotero kuti peputiyo imakhala yokhazikika.

Kodi ndi zosintha ziti zomwe zidasinthidwa polypeption zitha kuphatikizidwa ku China peptide?

Kampani yathu imapereka malo osiyanasiyana osinthika, monga acetylation, biossin, phosphorylation Kusinthana, kusintha kwa flurescence kusinthidwa, kungathenso kusinthidwa malinga ndi zosowa zanu zapadera.

Kodi mumasungunuka bwanji poizo?

Kusungunuka kwa polypeptide kumadalira makamaka kapangidwe kake, mtundu wa zilembo zosintha, mtundu wosinthika ndi ndende yomaliza. Ngati peptide ikapanda kuthekera m'madzi, ultrasound ingathandize kusungunuka. Chifukwa cha peptide woyambira, tikulimbikitsidwa kusungunuka ndi 10% acetic acid; Kwa acidic mapepu, kusungunuka ndi 10% nh4hco3 kumalimbikitsidwa. Ordic solt imathanso kuwonjezeredwanso kwa inlypeptions. Peptideyo imasungunuka pang'ono kuchepera (E.g., DMSO, DMF, isopropyl mowa, methanol, etc.). Ndikulimbikitsidwa kwambiri kuti peputiyi isungunuke mu solvel sorvent kenako kuwonjezeredwa pang'onopang'ono madzi kapena buffer ina mpaka chidwi chofuna.

Kodi mikhalidwe yabwino kwambiri yoteteza ndi iti? Kodi peptide imakhazikika bwanji?

Lyophilized, polypeptide imatha kupanga fluff kapena bondo, zomwe zingapewe kuwonongeka kwa polypeptide. Zoyenera Kusungirako: a. -20℃ kusungidwa kapena malo owuma b. Yesani kupewa kubwereza kwaulere. Yesani kupewa kusungidwa mu yankho (ufa wowuma ufa ungasungidwe m'matumba osiyana kuti mugwiritse ntchito) d. Ngati iyenera kusungidwa mu yankho, tikulimbikitsidwa kusungunula ma peptidel mu madzi osabala pansi pa zofooka za acidic ndi sitolo ku -20℃.

Kodi ndimasunga bwanji Peptives?
Kawikawiri Zogulitsa zomwe mumalandira ndi ma blovolilikizere ufa wa ufa, chonde sungani peptide youma, yamdima -20 ° Musanagwiritse ntchito, ikani chubu cha polyteptide kuchokera ku mkhalidwe wowuma firiji, ndikulola kutentha kuti kutentha kwachilengedwe chikhale chitumbu. Kupanda kutero, mpweya wamadzi mumlengalenga umalowa mu chubu cholowera pomwe chivindikiro chimatsegulidwa, ndikuchepetsa kukhazikika kwa peptide. Tinatsegulidwa, ziyenera kulemera mwachangu ndipo nthawi yomweyo tiike kuti zisakhale zokongola, ndipo nthawi yomweyo pepulilic maypsilic iyenera kukhala osamala kuti musatengedwe mobwerezabwereza. Kusachedwa kutentha panthawi yochepa kuyenda sikusokoneza moyo wa alumali ndi mtundu wa ma peptides.Kodi malangizo a peptides ndi ati?
P-tentsus akuchokera ku C-demingus mpaka zermilu wa polypeptide.

Kodi kulemera ndi chiyani? Kodi Peptide ndi chiyani?

Lophilided peptide nthawi zambiri imakhala yofananira komanso yofananira, itha kukhalabe ndi madzi okwanira, ma sosorbded ndi mchere chifukwa cha mawonekedwe a chipinda chomwecho. Izi sizitanthauza kuti kuyera kwa peptide sikokwanira, koma zomwe zomwe zimapezeka pa peptide zimachepetsedwa ndi 10% mpaka 30%. Kulemera kwa peptide ndi kulemera kwenikweni kwa peptide minuyi madzi ndi masitepe a masitepe. Pofuna kuonetsetsa kuti peptide, zinthu zomwe sizikufuna zilonda zimayenera kuchotsedwa ku poppa peptide.