ARA 290 ndi peptide yopanda erythropoietic yopangidwa kuchokera ku erythropoietin (EPO), timadzi timene timapangitsa kuti maselo ofiira a magazi apangidwe. Ndi mtundu wosinthidwa wa mahomoni obadwa mwachilengedwe, omwe apezeka kuti ali ndi neuroprotective effect. ARA 290 yawonetsedwa kuti ili ndi ntchito zingapo zochizira m'mikhalidwe yosiyanasiyana yaubongo.
Kuchiritsa mabala ndi njira yovuta, ndipo kuwongolera kutupa ndikofunikira pakuchira msanga. ARA-290, peptide yodula kwambiri yochokera ku erythropoietin (EPO), imapereka njira yopambana polimbikitsa kukonza minofu popanda kuopsa kokhudzana ndi chithandizo chachikhalidwe cha EPO.
Mosiyana ndi EPO, yomwe imapangitsa kupanga maselo ofiira a magazi ndipo imakhala ndi chiopsezo cha thrombosis, ARA-290 imayang'ana makamaka cholandilira cha EPOR-CD131 kuti chipereke mphamvu zoteteza minofu. Kafukufuku akuwonetsa kuti ARA-290 imatha kufulumizitsa machiritso a chilonda chapakhungu ndikuwongolera bwino kutupa.
Kafukufuku waposachedwa akuwonetsa njira yapadera ya ARA-290: imathandizira ntchito ya macrophages-maselo a chitetezo chamthupi omwe amachotsa maselo akufa kapena owonongeka. Mwa kulimbikitsa macrophage efferocytosis, ARA-290 imachepetsa zizindikiro zoyambitsa kutupa monga TNF-α, IL-6, ndi IL-1β, pamene zikuwonjezera zotsutsana ndi kutupa ndi kukonza minofu monga IL-10 ndi TGF-β1. Kuchita kwapawiri kumeneku sikungofulumizitsa kutsekedwa kwa bala komanso kumalimbikitsa kusinthika kwa minofu yathanzi.
M'maphunziro a nyama, mabala omwe amathandizidwa ndi ARA-290 adachira mwachangu motengera mlingo, kuwonetsa kuthekera kwake kothandizira kukonza kwachilengedwe kwa thupi. Kuchiza kwapamwamba kunafulumizitsa machiritso mogwira mtima kusiyana ndi mankhwala ochepetsetsa kapena kuwongolera koyenera, kutsimikizira kuthekera kwachire kwa ARA-290.
Ndi makina ake omwe akuwunikira, mbiri yachitetezo, komanso magwiridwe antchito otsimikizika, ARA-290 ikuyimira yankho lodalirika pakukonzanso khungu komanso kuwongolera mabala. Zimapereka chiyembekezo chatsopano kwa odwala ndi othandizira azaumoyo omwe akufuna chithandizo chamankhwala chothandizira, chothandizidwa ndi sayansi.
Buku
Chen H, Liang F, Wang J, et al. ARA290 imathandizira macrophage efferocytosis kulimbikitsa machiritso akhungu mu mbewa.Journal of Immunology, 2022, 38(07): 605-611. DOI:10.13431/j.cnki.immunol.j.20220083
Nthawi yotumiza: 2026-01-28