Zolemba Zaposachedwa Kwambiri pa Antimicrobial Peptide Ll-37

Kodi ma antimicrobial mapepu ndi chiyani?

Ma Peptickeri a antimicbichial, omwe amadziwikanso kuti antimickerial Peptides, ndi gawo lofunikira mu chitetezo cha mthupi la anthu. Amapezeka kwambiri m'zinthu zachilengedwe ndipo amapezeka zazing'ono zomwe zimapangidwa ndi zinthu zopangidwa ndi zinthu. Thupi la munthu limatulutsa mitundu iwiri ya antimicrobial mapepu: Demensin ndi cathelicidin. Demensin imaphatikizapo ma pepticrobial ma peptides, pomwe cathelicridin ali ndi imodzi mwazinamizira—37.

Kodi LL-37 ndi chiyani?

LL-37 ndi yekhayo amene anali ndi vuto lotsanzira lomwe lilipoli m'thupi la munthu. Imapangidwa ndi 37 amino acid ku n-termial wa protein, ndipo ma amno acid omwe ali ndi L-L, chifukwa chake dzina la LL-37.

Mapuloteni akuluakulu mu neutrophils ndipo amapezeka kwambiri mu neutrophils, mafupa, mikono, komanso mwapachiwawa. Chosangalatsa cha LL-37 chimakhala ndi peptional peptide, malo osungidwa owirira, ndi 37 amino admies. Maselo atayamba kugwira ntchito, bioatict ll-37 amapangidwa kudzera mu Cleavage popanga mapurotesitanti atatu ndi ma protengoc, komanso antifungul ndi immunostic / magwiridwe antchito.