Kupambana Kwatsopano kwa chithandizo cha Vitiligo! KPV Tripeptide Biomimetic Synergistic Synergistic Synergistic Syscts yomwe imapereka chiyembekezo chatsopano pakubwezeretsanso kwa pigmementation

Vitiligo ndi vuto lapadera lomwe lili ndi vuto la khungu lomwe limadziwika ndi kusokonekera kwapadera kapena kwakukulu chifukwa cha kuwonongeka kwa Melanocyte pakhungu, kumabweretsa zigamba zoyera. Kwa nthawi yayitali, chithandizo chomwe chilipo chakhala chikuyenda mokhazikika kwa Melanocytes kapena kukonza zamicreenment, kupanga vitiligo kovuta kwambiri muchipatala.

Pa Novembala 23, 2021 Gulu lofufuzidwa lotsogozedwa ndi Profescor du Cirner pa neomimetic njira ya Bililigo, yomwe ili pa magazini yapadziko lonse, yothandizira chithandizo cha Vitiligo.

Chovala cha Patrogeneis cha Vitiligo chimagona mu vislam yotupa chimayambitsa mitundu ya okosijeni (ros). Kupsinjika kwa oxida kumangowononga chilengedwe cha Melanocyte komanso kuyika mwachindunji melanocytes ndikulepheretsa kaphatikizidwe kwa melanin. Gawo lalikulu la chithandizo ichi ndi chidutswa chothandiza cha mahomoni olimbikitsa a Melanocyte—KPV Traptide. Monga chidutswa chogwiraa-Melacyte-yolimbikitsa mahone (a-

Gulu lofufuzira lomwe linapangidwa mwamphamvu liposomal lomwe limadzaza ndi polydopamine (PDA) losinthidwa ndi KPV Tripeptnisolone (Mps), kukhazikitsa njira yothandiza ya nanoscale yowonjezera. Liposomes iwo mwini ali ndi zabwino kwambiri, pomwe osinthika a KPV osinthidwa amakhala amamangirira ku Melanocyte, zomwe zimapangitsa kuti ma nanoscale apangidwe ndi Anchor ku Thorly pamalo a lesion. Izi zimathandizira kwambiri kusungidwa kwa mankhwala ndi kudzikundikira koyambira pakhungu. Pambuyo pakutulutsa mankhwala osokoneza bongo, otsalira a KPV otsalawo akupitiliza kugwira ntchito, kulimbikitsa melanocyte kuchuluka ndikuwonjezera kupanga menosome ndikupanga mphamvu, kukwaniritsa zotsatirapo zokhazikika.

Kafukufukuyu anali kuvomerezedwa bwino mu H₂O₂-Zinducked Vitiligo mbewa. Zotsatira zake zikawonetsa chithandizo ndi mawonekedwe a a Nanodrug osinthika, mitundu yotupa yazotupa yomwe imachepa, ndipo zoyera zoyera zidathanso kuyambiranso pigmentation. Ntchito yothandizira Melanocytes idakulitsidwa kwambiri, ndipo kuchuluka ndi kugawa melasosomes mkati mwa ma melaracocytes adasinthanso.

Pakadali pano, kafukufukuyu wasindikizidwa pa intaneti kutolankhani wapamwamba kwambiri a ACS Nano, kujambula chidwi chofananira ndi anthu ophunzira. Ndi kupita kwina kopitilira maphunziro otsatizana, kumakhulupirira kuti ma nanomediations awa, amatha kukhala ndi mankhwala azachipatala, omwe amabweretsa chiyembekezo kwa odwala omwe ali ndi Vitiligo padziko lonse lapansi!