Zogwira Zosakaniza za njuchi za njuchi
Mellitin ndiye gawo lalikulu la nyama ya njuchi. Venom njuchi ndi malo onunkhira bwino, owonekera kuchokera ku venom inters ndi tizilombo toyambitsa njuchi ndikumasulidwa ndi mbola zikaopsezedwa. Pali mitundu yambiri yazinthu za njuchi zoyikapo, zomwe zili m'magazini a njuchi zimakhala ndi zochulukirapo, zowerengera za 50% ya njuchi zowuma, ndipo zochita zake zachilengedwe ndi zamphamvu kwambiri. Melritrin amapangidwa ndi ma amino acid, omwe ndi chikhomo cholowera ndi 2849 amino acid. Kutsatira kwa amino acid ndi gigavlkvltglpalisprqq-NH2. Kanema wamakono wamankhwala adapeza kuti njuchi kunyama sizingokhala ndi zotupa ndi analgesic, komanso zimalepheretsa zovuta zamagetsi komanso zimalepheretsa Aifera. Imakhala ndi vuto lalikulu pama cell ambiri otupa kudzera pamachitidwe osiyanasiyana, ndipo ndi mankhwala osokoneza bongo omwe ali ndi ntchito yayikulu.
Antibacterial ndi antiviral amagwira ntchito
Njuchi za njuchi zimalepheretsa kukula kwa mabakiteriya 20 abwino komanso osalimbikitsa ndikuwonjezera mphamvu ya antibafiya ya sulfonamides ndi penicillins. Zowopsa za njuchi zimakwaniritsa mphamvu ya bactericidal pomanga ma bacranel a cumbranes ndikuwononga ma cell a cell. Kuphatikiza apo, Melitrin ndi zonunkhira zake zisanu ndi chimodzi zimatha kusintha ntchito ya magazi wa kachilombo ka Honerrhea, kuletsa kubwereza kwa HIV, kusokoneza kusokonekera kwa kachiromboka.
Zotsatira zoletsa
1. Zoyeserera zingapo zoyeserera za Vitro zawonetsa kuti m'magazi a njuchi ali ndi vuto lalikulu pama cell angapo otupa monga a khansa ya Ovaria, ndi glioma, ndipo izi zimagwirizana ndi mlingo. Ma cell a njuchi amagwira ntchito pomupha maselo otupa ndikuletsa kukula kwawo pomwe ali ndi vuto laling'ono kapena lowoneka bwino pakukula kwa maselo abwinobwino. Kafukufukuyu adazindikira kuti Pexin adatha kulowa mu cell membrane ya K562 maselo a K562, potengera kuchuluka kwa Ca2 + Kuphatikiza apo, Melritrin imatha kuletsa ntchito yopumira yopumira, ndikuwononga kuthekera kwa aerobic, moyenera kumalepheretsa kukula kwa khansa.
2. Chitetezo cha maselo mu immunomodulatory kuchitapo kanthu ndi mzere wofunikira wotetezera ku zotupa ndi matenda opatsirana mu thupi. Pakapangidwe chotupa ndi chitukuko, mkhalidwe wa mthupi la thupi umakhala wotsutsa. Kukweza ntchito ya mthupi la cellular kumatha kusewera ndi chotupa china chotupa.
3.Kuyika apopetosis a zotupa. Apoptosis, amadziwikanso kuti kumwalira kwa cell, ndi njira yogwiritsidwira ntchito yomwe imayendetsedwa ndi majini osiyanasiyana. Chifukwa apoptosis ndi njira yogwira, imaphatikizapo ntchito monga kutsegula, kufotokoza ndi kuwongolera kwa majini osiyanasiyana. Kafukufuku wamakono wasonyeza kuti mankhwala ambiri a chemotherapy amatha kukwaniritsa zochizira za avopetosis za maselo a khansa, kotero kuyika apopetosis kwakhala njira yofunika yowunikira mankhwala a khansa.
Njira zamankhwala za nyamakazi ya rheumatoid
1. Kuletsa ntchito yachinsinsi phospholipsese a2 (spla2) ndi yofunika kwambiri kumoyo, monga spla2 imasewera maudindo osiyanasiyana m'matenda, kuvulala, kutupa, zotupa, ndi khansa. Kafukufuku wawonetsa kuti aputoxin imalepheretsa ntchito ya Spla2 kuchokera ku magwero osiyanasiyana, kukwaniritsa kuchuluka kwa ma 96% mu synovial madzi ozizira (Ra). Chifukwa chake, kugwiritsa ntchito apitoxin kungathandize kuchepetsa kupsinjika kwa RA.
2. Cholepheretsa nembanemba kuwukira (Mac) mlingo wa apitoxin amatha kuchepetsa kwambiri mazenera omwe ali pafupi. Njira yoteteza iyi imatha kukwezedwa ndi apitoxin ya intracellular calcium ion (ca2 +) kuchuluka kwa mizere intracellular, ndikuwonjezera kwa kapangidwe kake katenthedwe oteteza. Zopeza izi zikusonyeza kuti kugwiritsa ntchito kwenikweni kwa avitoxin kungakhale ndi mtengo wina mankhwalawa matenda a nyamakazi (ra). Kafukufuku waposachedwa wasonyeza kuti kusiyanasiyana kosiyanasiyana kwa apitoxin kumatha kupangitsa kuti ma cell agwire ntchito m'njira zosiyanasiyana, zomwe zimapangitsa kuti ziphuphu zosiyanasiyana. Kugwiritsa ntchito mwanzeru za aputoxin kumatha kupereka njira zatsopano zachithandizo zoti matenda ena.
Zochita Zachilengedwe
Mellitin, woyambitsa phospholipsese a2 (pla2), amatha kukulitsa ntchito ya plank yotsika kwambiri koma ilibe mphamvu pa ntchito ya michere yamagetsi yayitali kwambiri.
Post Nthawi: 2025-08-06