Palmitoyl Tripeptide-1: Limbikitsani Kukhazikika Kwa Khungu Lanu!

Sanzikanani ndi makwinya osautsa omwe amakupangitsani kudzimvera chisoni. Palmitoyl Tripeptide-1 imachita ngati katswiri wosawoneka wosamalira khungu, yonyowa pang'onopang'ono mizere yabwino komanso makwinya akuya osayang'ana, ndikusiya khungu lanu kukhala losalala ngati dzira losenda - lowala kwambiri kotero kuti ngakhale galasi lingadabwe ndi mawonekedwe anu opanda chilema!

Makhalidwe Apangidwe

Palmitoyl Tripeptide-1 ndi chizindikiro peptide wopangidwa ndi conjugation wa atatu amino zidulo (glycine, lysine, ndi proline) ndi asidi palmitic, amatchedwanso palmitoyl oligopeptide. Palmitic acid, mafuta amtundu wautali wautali, amapatsa peptide ndi lipophilic properties, zomwe zimathandiza kuti zilowe m'kati mwa khungu mosavuta. Mapangidwe ake apadera a maselo amalola kuti azichita bwino pakhungu la dermis, zomwe zimalimbikitsa kaphatikizidwe ka zigawo za extracellular masanjidwewo monga kolajeni ndi glycosaminoglycans, potero kumapangitsa kuti khungu likhale lolimba komanso losalala.

Njira Yochitira

Palmitoyl Tripeptide-1 imamangiriza ku zolandilira zenizeni pamwamba pa maselo akhungu - zolandilira izi zimagwira ntchito ngati "ma switch" am'manja. Akamangiriza, amayamba kutsagana ndi njira zolumikizirana ndi ma intracellular:

• Kutsegula kwa njira ya TGF-β kumapangitsa ma fibroblasts kutulutsa kolajeni wochulukirapo, chinthu chofunikira kwambiri pakhungu chomwe chimathandizira pakukhazikika komanso kukhazikika, zomwe zimapangitsa kuti khungu likhale lolimba komanso lolimba.

• Kutsegula kwa njira ya MAPK kumalimbikitsa kupanga matrix metalloproteinases (MMPs). Ma enzymes awa amaphwanya kolajeni wakale pomwe amalimbikitsa ma fibroblasts kuti apange collagen yatsopano ndi glycosaminoglycans, amatsitsimutsa khungu ndikubwezeretsa kuwala kwake.

Kuphatikiza apo, Palmitoyl Tripeptide-1 imakhala ndi zotsatira zofanana ndi retinol (vitamini A), chinthu chodziwika bwino komanso chothandiza choletsa kukalamba chomwe chimathandizira kusintha kwa maselo ndikusinthanso khungu. Kupyolera mu makina ofanana, Palmitoyl Tripeptide-1 imakonzanso matrix a dermal, imalimbitsa khungu ndikuchepetsa mawonekedwe a makwinya.

Kutsimikizira Kuchita bwino

Kafukufuku wina wotchedwa Comprehensive Evaluation of the Efficacy and Safety of a Novel Multi-Ingredient Anti-Aging Eye Cream for Topical Use anasonyeza kuti Palmitoyl Tripeptide-1 ikhoza kulimbikitsa kaphatikizidwe ka zigawo zikuluzikulu za matrix a extracellular (ECM), kuphatikizapo mtundu Woyamba ndi mtundu wa III collagen, elastin, ndi structural glycoproteins (glycoproteins).

Kudetsa kwa Immunofluorescence kunagwiritsidwa ntchito kuyesa mphamvu ya collagen ndi elastin kaphatikizidwe kapangidwe. M'chithunzi A, poyerekeza ndi gulu lolamulira, mankhwala opangira mankhwala amawongolera kwambiri mawu a Col I ndi Col III mu human dermal fibroblasts (HDFs), monga momwe zimasonyezedwera ndi chizindikiro chowonjezera chofiira cha fluorescence.

Mwachidziwitso, mafotokozedwe a elastin adawonetsanso kusintha kwakukulu pambuyo pa chithandizo ndi mapangidwe. Kusanthula kachulukidwe kunatsimikiziranso kuwonjezeka kwakukulu kwa mawu a Col I, Col III ndi elastin pambuyo pa chithandizo (Chithunzi B).

Tsamba la Ntchito

Monga chopangira chothandiza kwambiri chothana ndi ukalamba, Palmitoyl Tripeptide-1 yakhala chinthu chodziwika bwino muzinthu zamakono zosamalira khungu, chifukwa cha kuthekera kwake kwa khungu komanso zochitika zosiyanasiyana zamoyo. Akagwiritsidwa ntchito monga momwe amachitira, amatha kusintha kwambiri khungu komanso kulimba, kuwonetsa khungu laling'ono, lathanzi komanso lowala kwambiri.

Maumboni

[1] https://pubmed.ncbi.nlm.nih.gov/38932444/
[2] https://www.sciencedirect.com/science/article/pii/S1773224723009395
[3] https://onlinelibrary.wiley.com/doi/10.1111/ics.12770