Udindo wa pseudo-proline dipepsides

Pseudo-proline masipesides ali ndi oxonides opangidwa kuchokera ku seriine kapena chisokonezo. Akamachita ndi trifluortic acid (tfa), oxananoles amasinthidwa kukhala serine kapena pachiwopsezo. Oxonoles ali ndi chofanana ndi chowonjezera ndipo akutchedwa pseudo-proline. Monga proline, pseudo-proline amapanga "kink" m'mphepete mwa msewu wa Peptide. Kink iyi imasokoneza ma hydchaen hydchaen homes yomwe imayambitsa kuphatikizika. Kuphatikiza pseudo-proline mu peptide kumathandizanso kuphatikiza mphamvu, motero kumalimbikitsa chiyero ndi zipatso za peputiyo. Kuphatikiza kwa pseudo-proline ndikovuta komanso zokolola nthawi zambiri zimakhala zochepa. Chifukwa chake, pseudo-proline imagwiritsidwa ntchito ngati pseudo-proline dipeptisi mu zokambirana za Peptide. 

Pseudopline imakhala yokhazikika pansi pa zovuta. Peptides okhala ndi ma pseudopline omwe amatha kukonzedwa pa 2-chlorotericlel restin kapena sieber ndikumatayidwa pamaso pa pseudomporline.

Poyerekeza ndi ma peptider ofananira, ma peptides okhala ndi pseudo-proline ali ndi zosungunuka bwino. Izi zimapangitsa ma peptide okhala ndi pseudo-proline yosavuta kuyeretsa ndikugwiritsa ntchito kaluso. Kuphatikiza apo, ma peptudes okhala ndi pseudo-proline pa C-terminus akhoza kulumikizidwa popanda kusinthika kwa zotsalira za C-termial. 

Dziwani za pseudo-proline mu mzere wamalor zimathandizira kupanga cycliclo. Zanenedwa kuti kuwonjezera kwa pseudo-proline kungakulitse zokolola za cyclic poptides ndipo imathandizira pakutha kwa chilengedwe. 

Pseudo-Proline amasokoneza maulalo a hydrogen m'bokosi loyambira. 

Pseudo-Proline imasokoneza maunyolo a hydrogen pakati pa zikopa za pa Peptide. 

Pseudo-proline amatseka mapangidwe a katsitsumgine yopangidwa ndi zinthu ndi zomwe zimapangidwa ndi kapangidwe ka katsitsumzukwa. Amagwiritsidwa ntchito mu gawo la Semi-synthesis a R2 Aumunit of Estherherisa Coli Ribonucleotide Resots. Njirayi yagwiritsidwa ntchito posachedwa pa kaphatikizidwe ka madera a glycopkhoptide ya erythrophen. 

Malangizo a kugwiritsa ntchito pseudopline dipeptide 

Ngati ndi kotheka, ikani pseudo-proline pamaso pa dera la hydrophobic. 

Payenera kukhala osachepera Acid Acid pakati pa pseudo-marline kapena pakati pa pseudo-proline ndi proline. 

Kutalika koyenera ndi ma 6 mpaka 6 amino acid pakati pa pseudo kapena pakati pa pseudo-proline ndi ochulukitsa.