Zojambula zopanga ndizofunikira pochizira matenda a sitiroko

Kafukufuku akuwonetsa kuti munthu aliyense padziko lapansi adzakhala ndi sitiroko, munthu m'modzi adzamwalira masekondi asanu ndi limodzi kapena apo, ndipo munthu m'modzi adzalemala moyo chifukwa cha stroko masekondi asanu ndi limodzi. Stroke ndi gulu la matenda omwe ali ndi matenda a ischemia ndipo hemorrthagic amawonongeka kwambiri, omwe amadziwikanso kuti miyendo kapena kusokonezeka kwa ziwonetsero, kusokonezeka kwamisala, kusokonekera kwakukulu komanso kusokonekera kwakukulu.

Stroke imasokoneza kwambiri moyo wa anthu komanso thanzi. "Thanombsultic mankhwala mkati mwa maola 4.5 tsopano ndi njira yolimbikitsira mwamphamvu kuti muwonongeke, koma pokhapokha mutagwiritsa ntchito neuroimagiging kuti musiyanitse ma strocrhagic strokes." Chifukwa chake, ndizosangalatsa kupeza chandamale wamba chochizira ischemic ndi hemorrhagic stroke.

Ofufuzawo adapanga peputiyi yomwe imasokoneza kapangidwe ka myeliod.

Zojambula zopanga ndizofunikira pochizira matenda a sitiroko

Tat-Cirp (TC) adateteza ubongo wa mbewa ndikuchepetsa ubongo wa magazi 28 patatha masiku a hemorrhagic poyerekeza ndi saline. MDE2 (Chosiyanitsa ndi Mdyeroid Protein 2) chimayambitsa ma necrosis mu neuron mu njira ziwiri zodziyimira pawokha.

Peptide ndi mapuloteni osinthika osinthika ozizira (Loti-Cirp). Ofufuzawo adatanthauzira zotsatira za mitsempha ya ischemic ndi hemorrhagic strokes mu mbewa m'njira ziwiri - mwa kupatsa mbewa ndi ma quirp ndi kuchotsa Mdj. Mumtundu wokulirapo wa nehehes, jekeseni wa Tat-Cirp adachepetsa kuchuluka kwa minofu yaubongo yofa ndikukhalabe ndi minyewa patadutsa masiku 30 pambuyo pa ischemic.

Ngati palibe chowonera mukamagwiritsa ntchito mlingo waukulu wa Loto-Cirp mu mbewa, zidawonetsa kuti tat-CRP imatha kulowamo magazi ndi chiwonetsero cha Stroke ochita bwino. Ngakhale ataperekedwa kwa maola 6 pambuyo pa sitiroko, Cirp adaletsa kutayika mosatekeseka komanso kuchepetsedwa kutaya minofu ya muubongo ndi mtundu wa ma hemorrhagic stroke.

Kuphatikiza apo, MD2 idawonetsedwa kuti ipangitse avongos avopetosis ndipo necroptosis kudzera pa tlr4-yodziyimira pawokha. Onse pamodzi, CIRT-CRP CRARDER REURERECRECRECTATIONVERCATIONVERCATIONAL CARECTER NDI SYRALEC SURDILIC STROK-yamunthu. Zoyesayesa ziyenera kukulitsidwa kuti zizitanthauzira zopeza izi posamalira odwala omwe ali ndi ischemic ndi hemorrhagic stroke.